| Phytophenols in whisky lower blood acetaldehyde level by depressing alcohol metabolism through inhibition of alcohol dehydrogenase 1 (class I) in mice. | |
| | |
MedLine Citation:
|
PMID: 19013301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We recently reported that the maturation of whisky prolongs the exposure of the body to a given dose of alcohol by reducing the rate of alcohol metabolism and thus lowers the blood acetaldehyde level (Alcohol Clin Exp Res. 2007;31:77s-82s). In this study, administration of the nonvolatile fraction of whisky was found to lower the concentration of acetaldehyde in the blood of mice by depressing alcohol metabolism through the inhibition of liver alcohol dehydrogenase (ADH). Four of the 12 phenolic compounds detected in the nonvolatile fraction (caffeic acid, vanillin, syringaldehyde, ellagic acid), the amounts of which increase during the maturation of whisky, were found to strongly inhibit mouse ADH 1 (class I). Their inhibition constant values for ADH 1 were 0.08, 7.9, 15.6, and 22.0 mumol/L, respectively, whereas that for pyrazole, a well-known ADH inhibitor, was 5.1 mumol/L. The 2 phenolic aldehydes and ellagic acid exhibited a mixed type of inhibition, whereas caffeic acid showed the competitive type. When individually administered to mice together with ethanol, each of these phytophenols depressed the elimination of ethanol, thereby lowering the acetaldehyde concentration of blood. Thus, it was demonstrated that the enhanced inhibition of liver ADH 1 due to the increased amounts of these phytophenols in mature whisky caused the depression of alcohol metabolism and a consequent lowering of blood acetaldehyde level. These substances are commonly found in various food plants and act as antioxidants and/or anticarcinogens. Therefore, the intake of foods rich in them together with alcohol may not only diminish the metabolic toxicity of alcohol by reducing both the blood acetaldehyde level and oxidative stress, but also help limit the amount of alcohol a person drinks by depressing alcohol metabolism. |
| | |
Authors:
|
Takeshi Haseba; Junichi Sugimoto; Shigeo Sato; Yuko Abe; Youkichi Ohno |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 57 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-17 Completed Date: 2008-12-09 Revised Date: 2009-05-19 |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 1753-9 Citation Subset: IM |
Affiliation:
|
Department of Legal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8602, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetaldehyde
/
blood*,
metabolism Alcohol Dehydrogenase / antagonists & inhibitors*, metabolism Alcoholic Beverages* Animals Benzaldehydes / pharmacokinetics Chemical Fractionation Down-Regulation / drug effects Ellagic Acid / pharmacokinetics Ethanol / pharmacokinetics* Liver / drug effects, enzymology, metabolism Male Mice Models, Biological Phenols / metabolism, pharmacology* Volatilization |
| Chemical | |
Reg. No./Substance:
|
0/Benzaldehydes; 0/Phenols; 121-33-5/vanillin; 476-66-4/Ellagic Acid; 64-17-5/Ethanol; 75-07-0/Acetaldehyde; EC 1.1.1.1/Alcohol Dehydrogenase |
| Comments/Corrections | |
Comment In:
|
Metabolism. 2009 Jun;58(6):889-90
[PMID:
19375127
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leucine, when ingested with glucose, synergistically stimulates insulin secretion and lowers blood g...
Next Document: Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus.