Document Detail


Phytonutrients for bone health during ageing.
MedLine Citation:
PMID:  23384080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteoporosis is a skeletal disease characterized by a decrease in bone mass and bone quality that predispose an individual to an increased risk of fragility fractures. Evidence demonstrating a positive link between certain dietary patterns (e.g. Mediterranean diet or high consumption of fruits and vegetables) and bone health highlights an opportunity to investigate their potential to protect against the deterioration of bone tissue during ageing. While the list of these phytonutrients is extensive, this review summarizes evidence on some which are commonly consumed and have gained increasing attention over recent years, including lycopene and various polyphenols (e.g. polyphenols from tea, grape seed, citrus fruit, olive and dried plum). Evidence to define a clear link between these phytonutrients and bone health is currently insufficient to generate precise dietary recommendations, owing to mixed findings or a scarcity in clinical data. Moreover, their consumption typically occurs within the context of a diet consisting of a mix of phytonutrients and other nutrients rather than in isolation. Future clinical trials that can apply a robust set of outcome measurements, including the determinants of bone strength, such as bone quantity (i.e. bone mineral density) and bone quality (i.e. bone turnover and bone microarchitecture), will help to provide a more comprehensive outlook on how bone responds to these various phytonutrients. Moreover, future trials that combine these phytonutrients with established bone nutrients (i.e. calcium and vitamin D) are needed to determine whether combined strategies can produce more robust effects on skeletal health.
Authors:
Sandra Maria Sacco; Marie-Noëlle Horcajada; Elizabeth Offord
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-08-06     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  697-707     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aging / physiology*
Bone Density / drug effects
Bone and Bones / drug effects*
Calcium, Dietary / pharmacology
Diet*
Diet, Mediterranean
Fruit / chemistry*
Humans
Micronutrients / administration & dosage*,  pharmacology
Osteoporosis / prevention & control*
Phytotherapy / methods
Vegetables / chemistry*
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/Micronutrients
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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