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Phytol-derived novel isoprenoid immunostimulants.
MedLine Citation:
PMID:  22566931     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice.
Authors:
Roshni Roy Chowdhury; Swapan K Ghosh
Publication Detail:
Type:  Journal Article     Date:  2012-03-22
Journal Detail:
Title:  Frontiers in immunology     Volume:  3     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49     Citation Subset:  -    
Affiliation:
Department of Biology, Indiana State University Terre Haute, IN, USA.
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