Document Detail


Phytohemagglutin-induced lymphocyte transformation in oral contraceptive users.
MedLine Citation:
PMID:  63929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phytohemagglutin (PHA)-induced lymphocyte transformation (PILT) was determined in 217 women taking oral contraceptives and 203 control women by means of the uptake of 3H-thymidine into DNA of lymphocytes cultured in heterologous serum. Depressed PILT responses were observed in oral contraceptive users as compared with age-matched controls, and the magnitude of depression correlated with the duration of oral contraception and was inversely related to the clinical progestagenic potency of the component steroids. An additional group of 21 women, tested within 1 year (mean 3 months) of cessation of oral contraception, showed persistent depression of PILT responses. Suppression of lymphocyte transformation in autologous as compared with homologous, normal serum suggests that serum inhibitory factors amy be important. We found no evidence for a direct suppressive in vitro effect of synthetic estrogens and gestagens. The prevalence of autoantibodies in oral contraceptive users was similar to that in control subjects.
Authors:
A J Keller; W J Irvine; J Jordan; N B Loudon
Related Documents :
3776969 - Increased incidence of adenocarcinoma of the cervix in young women in the united states.
24258219 - Some issues in inter-gender humiliation.
10899679 - Increasing incidence of oral cancer amongst young persons: what is the aetiology?
3730279 - Use of uv-a sunbeds for cosmetic tanning.
19780979 - Self-elimination of risk factors for recurrent vaginal candidosis.
1950589 - The effect of the alpha 2-hs-glycoprotein on the mitogen-induced lymphoblastic transfor...
12204399 - High prevalence of tungiasis in a poor neighbourhood in fortaleza, northeast brazil.
11918229 - Incidence of vertebral fracture in europe: results from the european prospective osteop...
15585429 - Characteristics of latino men who have sex with men on the internet who complete and dr...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  49     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autoantibodies
Child
Contraceptives, Oral / pharmacology*
Contraceptives, Oral, Synthetic / immunology,  pharmacology*
Depression, Chemical
Dinitrochlorobenzene / immunology
Drug Combinations
Estradiol Congeners / immunology,  pharmacology
Female
Humans
Immunity / drug effects
Immunity, Cellular / drug effects
Lectins / pharmacology
Lymphocyte Activation / drug effects*
Male
Middle Aged
Pregnancy
Progesterone Congeners / immunology,  pharmacology
alpha-Macroglobulins
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Contraceptives, Oral; 0/Contraceptives, Oral, Synthetic; 0/Drug Combinations; 0/Estradiol Congeners; 0/Lectins; 0/Progesterone Congeners; 0/alpha-Macroglobulins; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nile blue and fetal maturity. Further investigations.
Next Document:  New experiences with bleomycin