Document Detail

Phytohemagglutin-induced lymphocyte transformation in oral contraceptive users.
MedLine Citation:
PMID:  63929     Owner:  NLM     Status:  MEDLINE    
Phytohemagglutin (PHA)-induced lymphocyte transformation (PILT) was determined in 217 women taking oral contraceptives and 203 control women by means of the uptake of 3H-thymidine into DNA of lymphocytes cultured in heterologous serum. Depressed PILT responses were observed in oral contraceptive users as compared with age-matched controls, and the magnitude of depression correlated with the duration of oral contraception and was inversely related to the clinical progestagenic potency of the component steroids. An additional group of 21 women, tested within 1 year (mean 3 months) of cessation of oral contraception, showed persistent depression of PILT responses. Suppression of lymphocyte transformation in autologous as compared with homologous, normal serum suggests that serum inhibitory factors amy be important. We found no evidence for a direct suppressive in vitro effect of synthetic estrogens and gestagens. The prevalence of autoantibodies in oral contraceptive users was similar to that in control subjects.
A J Keller; W J Irvine; J Jordan; N B Loudon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  49     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  AIM; IM    
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MeSH Terms
Contraceptives, Oral / pharmacology*
Contraceptives, Oral, Synthetic / immunology,  pharmacology*
Depression, Chemical
Dinitrochlorobenzene / immunology
Drug Combinations
Estradiol Congeners / immunology,  pharmacology
Immunity / drug effects
Immunity, Cellular / drug effects
Lectins / pharmacology
Lymphocyte Activation / drug effects*
Middle Aged
Progesterone Congeners / immunology,  pharmacology
Reg. No./Substance:
0/Autoantibodies; 0/Contraceptives, Oral; 0/Contraceptives, Oral, Synthetic; 0/Drug Combinations; 0/Estradiol Congeners; 0/Lectins; 0/Progesterone Congeners; 0/alpha-Macroglobulins; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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