Document Detail

Phytoestrogens and endometrial hyperplasia.
MedLine Citation:
PMID:  16607696     Owner:  HSR     Status:  MEDLINE    
(1) Short-term clinical trials have shown that soy phytoestrogens have a slight preventive effect on hot flushes. However, this finding is based on a low level of evidence. (2) A double-blind placebo-controlled trial involving about 300 women and lasting 5 years showed that phytoestrogens were associated with an increase in the incidence of endometrial hyperplasia (3.8% versus 0%). (3) In practice, the risk-benefit ratio of phytoestrogens has not been adequately assessed. Their effect on the endometrium, and the many unknowns concerning the risk of thromboembolism and breast cancer, may offset the modest effect of phytoestrogens on hot flushes.
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  15     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-04-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  62-3     Citation Subset:  T    
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MeSH Terms
Clinical Trials as Topic
Cost-Benefit Analysis
Endometrial Hyperplasia / chemically induced*
Hot Flashes / drug therapy*
Isoflavones / administration & dosage,  adverse effects*,  therapeutic use
Phytoestrogens / administration & dosage,  adverse effects*,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Isoflavones; 0/Phytoestrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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