Document Detail

Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfolk.
MedLine Citation:
PMID:  20494649     Owner:  NLM     Status:  MEDLINE    
Phytoestrogens are polyphenolic secondary plant metabolites that have structural and functional similarities to 17beta-oestradiol and have been associated with a protective effect against hormone-related cancers. Most foods in the UK only contain small amounts of phytoestrogens (median content 21 microg/100 g) and the highest content is found in soya and soya-containing foods. The highest phytoestrogen content in commonly consumed foods is found in breads (average content 450 microg/100 g), the main source of isoflavones in the UK diet. The phytoestrogen consumption in cases and controls was considerably lower than in Asian countries. No significant associations between phytoestrogen intake and breast cancer risk in a nested case-control study in EPIC Norfolk were found. Conversely, colorectal cancer risk was inversely associated with enterolignan intake in women but not in men. Prostate cancer risk was positively associated with enterolignan intake, however this association became non-significant when adjusting for dairy intake, suggesting that enterolignans can act as a surrogate marker for dairy or calcium intake.
Heather A Ward; Gunter G C Kuhnle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-06-01
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  501     ISSN:  1096-0384     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-09-20     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170-5     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Breast Neoplasms / etiology*,  prevention & control
Case-Control Studies
Colorectal Neoplasms / etiology*,  prevention & control
Food Analysis
Great Britain
Isoflavones / administration & dosage,  adverse effects
Lignans / administration & dosage,  adverse effects
Middle Aged
Phytoestrogens / administration & dosage*,  adverse effects*
Prostatic Neoplasms / etiology*,  prevention & control
Risk Factors
Grant Support
G0500300//Medical Research Council; MC_U105630924//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Isoflavones; 0/Lignans; 0/Phytoestrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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