Document Detail

Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
MedLine Citation:
PMID:  22477188     Owner:  NLM     Status:  In-Data-Review    
On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-Op-coumaroylquinic acid (46.10 ± 4.22 mg/g of dried weight) among CQs tested. The IC50 of the water-ethanol (7:3) extract was 4.23 ± 0.24 μg/mL in the peroxynitrite (ONOO(-))-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite-scavenging mechanism.
Agung Nugroho; Myung-Hoe Kim; Jongwon Choi; Jae Sue Choi; Won Tae Jung; Kyung-Tae Lee; Hee-Juhn Park
Related Documents :
18504978 - Evidence for incorporation of h2s in groundwater fulvic acids from stable isotope ratio...
22711758 - The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases ...
11869798 - A simple and rapid assay of collagen-like polymer in crude lysate from escherichia coli.
3944078 - Asparaginyl-n-acetylgalactosamine. linkage unit of halobacterial glycosaminoglycan.
11837988 - Short-term folic acid supplementation induces variable and paradoxical changes in plasm...
10425118 - Aurantosides d, e, and f: new antifungal tetramic acid glycosides from the marine spong...
Publication Detail:
Type:  Journal Article     Date:  2012-04-05
Journal Detail:
Title:  Archives of pharmacal research     Volume:  35     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  423-30     Citation Subset:  IM    
Department of Agro-industrial Technology, Faculty of Agriculture, Lambung Mangkurat University, Indonesia, 70714, Banjarmasin.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A new flavonol glycoside from Hylomecon vernalis.
Next Document:  Biologically active C-alkylated flavonoids from Dodonaea viscosa.