Document Detail


Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
MedLine Citation:
PMID:  22477188     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-Op-coumaroylquinic acid (46.10 ± 4.22 mg/g of dried weight) among CQs tested. The IC50 of the water-ethanol (7:3) extract was 4.23 ± 0.24 μg/mL in the peroxynitrite (ONOO(-))-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite-scavenging mechanism.
Authors:
Agung Nugroho; Myung-Hoe Kim; Jongwon Choi; Jae Sue Choi; Won Tae Jung; Kyung-Tae Lee; Hee-Juhn Park
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Publication Detail:
Type:  Journal Article     Date:  2012-04-05
Journal Detail:
Title:  Archives of pharmacal research     Volume:  35     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  423-30     Citation Subset:  IM    
Affiliation:
Department of Agro-industrial Technology, Faculty of Agriculture, Lambung Mangkurat University, Indonesia, 70714, Banjarmasin.
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