| Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. | |
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MedLine Citation:
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PMID: 12495710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two ethanolic propolis extracts (EPE) with and without the caffeic acid phenethyl ester (CAPE), CAPE and galangin (major components of propolis) were investigated for anti-inflammatory activity in rats using carrageenin foot oedema, carrageenin pleurisy and adjuvant arthritis. In our experiments, EPE with CAPE and CAPE alone significantly inhibited carrageenin oedema, carrageenin pleurisy and adjuvant arthritis. In contrast EPE without CAPE and galangin did not exhibit anti-inflammatory effects in acute and chronic inflammation. These results suggest that the anti-inflammatory activity of propolis is due to CAPE. |
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Authors:
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F Borrelli; P Maffia; L Pinto; A Ianaro; A Russo; F Capasso; A Ialenti |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fitoterapia Volume: 73 Suppl 1 ISSN: 0367-326X ISO Abbreviation: Fitoterapia Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2003-01-21 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 16930290R Medline TA: Fitoterapia Country: Netherlands |
Other Details:
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Languages: eng Pagination: S53-63 Citation Subset: IM |
Affiliation:
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Department of Experimental Pharmacology, University of Naples 'Federico II', Via D. Montesano 49, 80131, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Anti-Inflammatory Agents / administration & dosage, chemistry, pharmacology*, therapeutic use Arthritis / chemically induced, prevention & control* Caffeic Acids / administration & dosage, chemistry, pharmacology, therapeutic use Carrageenan / diagnostic use Cell Division / drug effects Chronic Disease Edema / chemically induced, prevention & control* Flavonoids / administration & dosage, chemistry, pharmacology, therapeutic use Male Phenylethyl Alcohol / administration & dosage, analogs & derivatives*, chemistry, pharmacology, therapeutic use Phytotherapy* Plant Extracts / administration & dosage, chemistry, pharmacology, therapeutic use Pleurisy / chemically induced, prevention & control* Propolis / administration & dosage, chemistry, pharmacology*, therapeutic use Rats Rats, Inbred Lew Rats, Wistar T-Lymphocytes / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Caffeic Acids; 0/Flavonoids; 0/Plant Extracts; 104594-70-9/caffeic acid phenethyl ester; 548-83-4/galangin; 60-12-8/Phenylethyl Alcohol; 9000-07-1/Carrageenan; 9009-62-5/Propolis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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