| Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil. | |
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MedLine Citation:
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PMID: 11536374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The composition of eight samples of commercial copaiba oils, used in the Amazonian region as antiinflammatory agents and available in popular markets, were analysed by gas chromatography/mass spectrometry (HRGC-MS). Major differences were observed in their chemical composition and some adulterations were pointed out. When tested in vivo oils 1 and 3, and to a lesser extent oil 6, significantly inhibited bradykinin-induced oedema formation. The other tested oils had no effect. When assessed in carrageenan-induced oedema formation, oils 1, 2 and 6, but not oil 3, significantly attenuated the oedema formation. The other tested oils failed to affect carrageenan-induced paw oedema. Oils 1 and 6 were further fractionated and several sesquiterpenes and diterpenes were detected. It is suggested that the naturally occurring sesquiterpenes present in the copaiba oils seem to be responsible for the antiinflammatory action reported in the folk medicine. Furthermore, our results clearly show an adulteration in copaiba oils available in Brazil. |
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Authors:
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V F Veiga; L Zunino; J B Calixto; M L Patitucci; A C Pinto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 15 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-05 Completed Date: 2002-01-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 476-80 Citation Subset: IM |
Copyright Information:
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Copyright 2001 John Wiley & Sons, Ltd. |
Affiliation:
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Institute of Chemistry, Universidade Federal do Rio de Janeiro, 21945-970 Rio de Janeiro, RJ, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / chemistry, pharmacology Bradykinin / pharmacology Brazil Carrageenan / pharmacology Diterpenes / analysis, chemistry Drug Contamination Edema / chemically induced, drug therapy* Fabaceae* Gas Chromatography-Mass Spectrometry Herbal Medicine Inflammation / drug therapy Male Phytotherapy Plant Oils / chemistry*, therapeutic use Plants, Medicinal Rats Rats, Wistar Sesquiterpenes / analysis, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Diterpenes; 0/Plant Oils; 0/Sesquiterpenes; 58-82-2/Bradykinin; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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