Document Detail

Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil.
MedLine Citation:
PMID:  11536374     Owner:  NLM     Status:  MEDLINE    
The composition of eight samples of commercial copaiba oils, used in the Amazonian region as antiinflammatory agents and available in popular markets, were analysed by gas chromatography/mass spectrometry (HRGC-MS). Major differences were observed in their chemical composition and some adulterations were pointed out. When tested in vivo oils 1 and 3, and to a lesser extent oil 6, significantly inhibited bradykinin-induced oedema formation. The other tested oils had no effect. When assessed in carrageenan-induced oedema formation, oils 1, 2 and 6, but not oil 3, significantly attenuated the oedema formation. The other tested oils failed to affect carrageenan-induced paw oedema. Oils 1 and 6 were further fractionated and several sesquiterpenes and diterpenes were detected. It is suggested that the naturally occurring sesquiterpenes present in the copaiba oils seem to be responsible for the antiinflammatory action reported in the folk medicine. Furthermore, our results clearly show an adulteration in copaiba oils available in Brazil.
V F Veiga; L Zunino; J B Calixto; M L Patitucci; A C Pinto
Related Documents :
17995634 - The effect of transglutaminase crosslinking on the rheological characteristics of heate...
16334324 - Insecticidal activity of selected monoterpenoids and rosemary oil to agriotes obscurus ...
17448504 - Long-term biological effects of petroleum residues on fiddler crabs in salt marshes.
8303954 - Inhibitory effect of spice oils on lipase and mycotoxin production.
22222824 - Thraustochytrids, a neglected component of organic matter decomposition and food webs i...
24734914 - Effects of chitosan-essential oil coatings on safety and quality of fresh blueberries.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  15     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-05     Completed Date:  2002-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  476-80     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Institute of Chemistry, Universidade Federal do Rio de Janeiro, 21945-970 Rio de Janeiro, RJ, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Inflammatory Agents / chemistry,  pharmacology
Bradykinin / pharmacology
Carrageenan / pharmacology
Diterpenes / analysis,  chemistry
Drug Contamination
Edema / chemically induced,  drug therapy*
Gas Chromatography-Mass Spectrometry
Herbal Medicine
Inflammation / drug therapy
Plant Oils / chemistry*,  therapeutic use
Plants, Medicinal
Rats, Wistar
Sesquiterpenes / analysis,  chemistry
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Diterpenes; 0/Plant Oils; 0/Sesquiterpenes; 58-82-2/Bradykinin; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Flavonoids--a new direction for the treatment of fluid retention?
Next Document:  Inhibitory effects of Korean plants on HIV-1 activities.