Document Detail

Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil.
MedLine Citation:
PMID:  11536374     Owner:  NLM     Status:  MEDLINE    
The composition of eight samples of commercial copaiba oils, used in the Amazonian region as antiinflammatory agents and available in popular markets, were analysed by gas chromatography/mass spectrometry (HRGC-MS). Major differences were observed in their chemical composition and some adulterations were pointed out. When tested in vivo oils 1 and 3, and to a lesser extent oil 6, significantly inhibited bradykinin-induced oedema formation. The other tested oils had no effect. When assessed in carrageenan-induced oedema formation, oils 1, 2 and 6, but not oil 3, significantly attenuated the oedema formation. The other tested oils failed to affect carrageenan-induced paw oedema. Oils 1 and 6 were further fractionated and several sesquiterpenes and diterpenes were detected. It is suggested that the naturally occurring sesquiterpenes present in the copaiba oils seem to be responsible for the antiinflammatory action reported in the folk medicine. Furthermore, our results clearly show an adulteration in copaiba oils available in Brazil.
V F Veiga; L Zunino; J B Calixto; M L Patitucci; A C Pinto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  15     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-05     Completed Date:  2002-01-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  476-80     Citation Subset:  IM    
Copyright Information:
Copyright 2001 John Wiley & Sons, Ltd.
Institute of Chemistry, Universidade Federal do Rio de Janeiro, 21945-970 Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Anti-Inflammatory Agents / chemistry,  pharmacology
Bradykinin / pharmacology
Carrageenan / pharmacology
Diterpenes / analysis,  chemistry
Drug Contamination
Edema / chemically induced,  drug therapy*
Gas Chromatography-Mass Spectrometry
Herbal Medicine
Inflammation / drug therapy
Plant Oils / chemistry*,  therapeutic use
Plants, Medicinal
Rats, Wistar
Sesquiterpenes / analysis,  chemistry
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Diterpenes; 0/Plant Oils; 0/Sesquiterpenes; 58-82-2/Bradykinin; 9000-07-1/Carrageenan

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