Document Detail

Phyto-oestrogens and osteoporosis: what is a safe dose?
MedLine Citation:
PMID:  12725659     Owner:  NLM     Status:  MEDLINE    
Hormone replacement therapy (HRT) for preventing loss of bone following the menopause is utilised by only 8-10 % of possible users, largely due to a fear of increased risk of breast cancer. Plant oestrogen-like compounds (phyto-oestrogens) have been proposed as an alternative to HRT to prevent osteoporosis. One class of phyto-oestrogens (the isoflavones) is found in soya foods and red clover. The food industry is developing a wide variety of new foods containing soya to substantially increase isoflavone intake, as well as extracting isoflavones from soya and clover to use as additives to non-soya foods. Pharmaceutical companies are also preparing isoflavone extracts to be used in pill form. In each case the targeted delivery is approximately 50 mg of isoflavones/d. Is this dose of isoflavones safe? In this review of the current literature, it is concluded that isoflavones consumed orally and in doses below 2 mg/kg body weight per d should be considered safe for most population groups. Whether these doses are sufficient to prevent osteoporosis is a separate matter.
Stephen Barnes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  89 Suppl 1     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-02     Completed Date:  2003-07-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  S101-8     Citation Subset:  IM    
Department of Pharmacology & Toxicology, and Comprehensive Cancer Center, University of Alabama at Birmingham, 35294, USA.
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MeSH Terms
Breast Neoplasms / prevention & control
Isoflavones / administration & dosage*,  adverse effects,  blood
Middle Aged
Neoplasms, Hormone-Dependent / prevention & control
Osteoporosis, Postmenopausal / prevention & control*
Soybeans / chemistry
Grant Support
5R01 CA-61668/CA/NCI NIH HHS; P50 AT00477-01/AT/NCCAM NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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