Document Detail


Phytic acid protects porcine intestinal epithelial cells from deoxynivalenol (DON) cytotoxicity.
MedLine Citation:
PMID:  20971622     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the effects of phytic acid (IP(6)) as a possible inhibitor of cellular damage induced by toxic substances such as mycotoxins on a porcine intestinal epithelial cell line (IPEC-1). We first observed that a dose of 5mM phytic acid decreases cell viability and transepithelial electrical resistance (TEER) of cell monolayer. We next investigate the effect of non-cytotoxic dose of phytic acid on the deoxinivalenol (DON) induced decreased TEER. We showed that treatment with 0.5mM or 1.0mM phytic acid restores the decrease in TEER caused by 25μM DON. In conclusion this study demonstrates that phytic acid decreased the negative effects of deoxynivalenol on the membrane integrity of the IPEC-1 intestinal epithelial cell line.
Authors:
Graziela Drociunas Pacheco; Caio Abércio da Silva; Philippe Pinton; Isabelle P Oswald; Ana Paula Frederico Rodrigues Loureiro Bracarense
Publication Detail:
Type:  Journal Article     Date:  2010-10-23
Journal Detail:
Title:  Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie     Volume:  64     ISSN:  1618-1433     ISO Abbreviation:  Exp. Toxicol. Pathol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208920     Medline TA:  Exp Toxicol Pathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  345-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier GmbH. All rights reserved.
Affiliation:
Universidade Estadual de Londrina, Centro de Ciências Agrárias, Campus Universitário, Londrina, CX Postal 6001, Brazil.
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