Document Detail

Physostigmine as a discriminative cue in rats.
MedLine Citation:
PMID:  1267546     Owner:  NLM     Status:  MEDLINE    
Rats, trained to respond differentially in a T-maze contingent upon the presence or absence of physostigmine (0.50 mg/kg), showed a reversal of drug responding when physostigmine (0.50 mg/kg) was given simultaneously with the anticholinergic ditran (dose range: 0.80-3.20 mg/kg). Testing the quaternary anticholinesterase neostigmine (0.50 mg/kg) resulted in no drug responding which indicates a central site of action for the physostigmine discrimination.
J O Johansson; T U Järbe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  219     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / antagonists & inhibitors
Avoidance Learning / drug effects
Discrimination (Psychology) / drug effects*
Glycolates / pharmacology
Neostigmine / pharmacology
Physostigmine / pharmacology*
Piperidines / pharmacology
Pyrrolidines / pharmacology
Time Factors
Reg. No./Substance:
0/Glycolates; 0/Piperidines; 0/Pyrrolidines; 51-84-3/Acetylcholine; 57-47-6/Physostigmine; 59-99-4/Neostigmine

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