Document Detail

Physiopathology and treatment of chronic cor pulmonale due to dysventilation syndrome.
MedLine Citation:
PMID:  2614878     Owner:  NLM     Status:  MEDLINE    
133 patients with chronic cor pulmonale due to dysventilation syndrome were studied. Chronic obstructive pulmonary disease (COPD) was found, possibly for the first time in Japan, to be the most common etiological condition, occurring in 54% of the patients. Chronic cor pulmonale was clinically diagnosed as the appearance of right heart failure on admission. Patients were divided into two groups depending on clinical state, compensated and decompensated. There was a marked difference in arterial blood gases and electrocardiographic fluctuations between the states. Serial observations of these parameters and enlarged cardiac silhouette to the left on plain chest film provided diagnostic evidence for development to the decompensated state. Pulmonary artery pressure changes on exercise and during sleep at night has been considered to impair right heart function. Prognosis of chronic cor pulmonale largely depends on the concentrated therapy of the decompensated state. 85% of patients in the current study returned to the compensated state with active intensive therapy. Recent therapeutic progress has made control of this serious disease possible, despite the appearance of right heart failure. Laborious prolonged therapy appears to be essential in order to improve long-term prognosis.
T Kunieda; M Naito; T Yoshioka; S Okubo; N Nakanishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  53     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-02     Completed Date:  1990-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1298-309     Citation Subset:  IM    
Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan.
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MeSH Terms
Aged, 80 and over
Asphyxia / complications*
Blood Gas Analysis
Chronic Disease
Lung Diseases, Obstructive / complications
Middle Aged
Pulmonary Heart Disease / etiology,  physiopathology*,  therapy
Pulmonary Wedge Pressure
Respiratory Function Tests

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