| Physiopathology of the cochlear microcirculation. | |
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MedLine Citation:
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PMID: 21875658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature. |
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Authors:
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Xiaorui Shi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-08-23 |
Journal Detail:
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Title: Hearing research Volume: 282 ISSN: 1878-5891 ISO Abbreviation: Hear. Res. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-05 Completed Date: 2012-04-02 Revised Date: 2012-04-20 |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 10-24 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Oregon Hearing Research Center (NRC04), Department of Otolaryngology/Head & Neck Surgery, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. Shix@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cochlea / blood supply* Hearing Disorders / metabolism, pathology, physiopathology* Humans Microcirculation* Microvessels / metabolism, pathology, physiopathology* Regional Blood Flow |
| Grant Support | |
ID/Acronym/Agency:
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DC008888S1/DC/NIDCD NIH HHS; P30-DC005983.DC 00105/DC/NIDCD NIH HHS; R01 DC000105-37/DC/NIDCD NIH HHS; R01 DC00105/DC/NIDCD NIH HHS; R01 DC010844-01A1/DC/NIDCD NIH HHS; R01 DC010844-02/DC/NIDCD NIH HHS; R01 DC010844-03/DC/NIDCD NIH HHS; R01-NIDCD DC010844//PHS HHS; R03 DC008888-01A1/DC/NIDCD NIH HHS; R03 DC008888-02/DC/NIDCD NIH HHS; R03 DC008888-02S1/DC/NIDCD NIH HHS; R03 DC008888-03/DC/NIDCD NIH HHS; R03-DC008888/DC/NIDCD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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