| Physiology and pharmacology of myocardial preconditioning. | |
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MedLine Citation:
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PMID: 20472628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perioperative myocardial ischemia and infarction are not only major sources of morbidity and mortality in patients undergoing surgery but also important causes of prolonged hospital stay and resource utilization. Ischemic and pharmacological preconditioning and postconditioning have been known for more than two decades to provide protection against myocardial ischemia and reperfusion and limit myocardial infarct size in many experimental animal models, as well as in clinical studies (1-3). This paper will review the physiology and pharmacology of ischemic and drug-induced preconditioning and postconditioning of the myocardium with special emphasis on the mechanisms by which volatile anesthetics provide myocardial protection. Insights gained from animal and clinical studies will be presented and reviewed and recommendations for the use of perioperative anesthetics and medications will be given. |
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Authors:
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Jacob Raphael |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in cardiothoracic and vascular anesthesia Volume: 14 ISSN: 1940-5596 ISO Abbreviation: Semin Cardiothorac Vasc Anesth Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9807630 Medline TA: Semin Cardiothorac Vasc Anesth Country: United States |
Other Details:
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Languages: eng Pagination: 54-9 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Virginia Health Center, Charlottesville, VA 22908-0710, USA. jr5ef@virginia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Inhalation
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administration & dosage,
therapeutic use Animals Humans Ischemic Preconditioning, Myocardial / methods* Length of Stay Myocardial Infarction / prevention & control* Myocardial Ischemia / prevention & control* Myocardial Reperfusion Injury / prevention & control Perioperative Care / methods Postoperative Complications / prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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