Document Detail

Physiology and pharmacology of myocardial preconditioning.
MedLine Citation:
PMID:  20472628     Owner:  NLM     Status:  MEDLINE    
Perioperative myocardial ischemia and infarction are not only major sources of morbidity and mortality in patients undergoing surgery but also important causes of prolonged hospital stay and resource utilization. Ischemic and pharmacological preconditioning and postconditioning have been known for more than two decades to provide protection against myocardial ischemia and reperfusion and limit myocardial infarct size in many experimental animal models, as well as in clinical studies (1-3). This paper will review the physiology and pharmacology of ischemic and drug-induced preconditioning and postconditioning of the myocardium with special emphasis on the mechanisms by which volatile anesthetics provide myocardial protection. Insights gained from animal and clinical studies will be presented and reviewed and recommendations for the use of perioperative anesthetics and medications will be given.
Jacob Raphael
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cardiothoracic and vascular anesthesia     Volume:  14     ISSN:  1940-5596     ISO Abbreviation:  Semin Cardiothorac Vasc Anesth     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807630     Medline TA:  Semin Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  54-9     Citation Subset:  IM    
Department of Anesthesiology, University of Virginia Health Center, Charlottesville, VA 22908-0710, USA.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage,  therapeutic use
Ischemic Preconditioning, Myocardial / methods*
Length of Stay
Myocardial Infarction / prevention & control*
Myocardial Ischemia / prevention & control*
Myocardial Reperfusion Injury / prevention & control
Perioperative Care / methods
Postoperative Complications / prevention & control
Reg. No./Substance:
0/Anesthetics, Inhalation

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