| Physiology and pharmacology of melatonin in relation to biological rhythms. | |
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MedLine Citation:
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PMID: 19605939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Melatonin is an evolutionarily conserved molecule that serves a time-keeping function in various species. In vertebrates, melatonin is produced predominantly by the pineal gland with a marked circadian rhythm that is governed by the central circadian pacemaker (biological clock) in the suprachiasmatic nuclei of the hypothalamus. High levels of melatonin are normally found at night, and low levels are seen during daylight hours. As a consequence, melatonin has been called the "darkness hormone". This review surveys the current state of knowledge regarding the regulation of melatonin synthesis, receptor expression, and function. In particular, it addresses the physiological, pathological, and therapeutic aspects of melatonin in humans, with an emphasis on biological rhythms. |
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Authors:
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Jolanta B Zawilska; Debra J Skene; Josephine Arendt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pharmacological reports : PR Volume: 61 ISSN: 1734-1140 ISO Abbreviation: Pharmacol Rep Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-07-16 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234999 Medline TA: Pharmacol Rep Country: Poland |
Other Details:
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Languages: eng Pagination: 383-410 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, Medical University of Łódź, Muszyńskiego 1, PL 90-151 Łódź, Poland. jolanta.zawilska@umed.lodz.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arylalkylamine N-Acetyltransferase / physiology Circadian Rhythm / drug effects*, physiology* Depression / drug therapy, physiopathology Humans Light Signal Transduction Melatonin / biosynthesis, pharmacology*, physiology*, therapeutic use Molecular Structure Photoperiod Pineal Gland / physiology*, physiopathology Receptors, Melatonin / agonists, antagonists & inhibitors, classification, metabolism Seasons Sleep Disorders / drug therapy, physiopathology Suprachiasmatic Nucleus / metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Melatonin; 73-31-4/Melatonin; EC 2.3.1.87/Arylalkylamine N-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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