Document Detail

Physiology and pharmacology of iodized oil in goiter prophylaxis.
MedLine Citation:
PMID:  11204500     Owner:  NLM     Status:  MEDLINE    
Thyroid complications resulting from excess iodide such as thyrotoxicosis, thyroiditis, sialadenitis, or hypothyroidism are much rarer after iodine supplementation with Lipiodol than with KI. They do not militate against its widespread use in endemic goiter populations, especially in pregnant women. However, patients with multinodular goiter should not be treated or should be treated only under careful observation. When Lipiodol-induced thyrotoxicosis occurs it tends to be mild or even subclinical and self-limited. If treatment is required, potassium perchlorate with or without thionamides is recommended. Iodide goiter has not been seen after Lipiodol supplementation, nor has thyroiditis. Sialadenitis occurs rarely. Iodide derived from Lipiodol readily enters the fetus, possibly by active transport, and theoretically endangers the fetus because autoregulation of the fetal thyroid occurs late during gestation. Despite the difficulty in distinguishing iodide goiter from iodide deficiency goiter of the newborn, no cases of neonatal iodide goiter have been reported. Possible mechanisms of thyroid inhibition by excess iodide are briefly discussed. The use of locally produced iodized plant oils is recommended for financial reasons as well as for the benefits derived from local participation.
J Wolff
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicine     Volume:  80     ISSN:  0025-7974     ISO Abbreviation:  Medicine (Baltimore)     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-05     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985248R     Medline TA:  Medicine (Baltimore)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-36     Citation Subset:  AIM; IM    
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8, Room 2A23, 9000 Rockville Pike, Bethesda, MD 20892, USA.
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MeSH Terms
Goiter / complications,  metabolism*,  prevention & control*
Hypothyroidism / etiology
Infant, Newborn
Iodine / deficiency
Iodized Oil / adverse effects*,  chemistry,  pharmacokinetics*
Maternal-Fetal Exchange
Sialadenitis / etiology
Thyroid Diseases / etiology
Thyrotoxicosis / etiology
Reg. No./Substance:
7553-56-2/Iodine; 8001-40-9/Iodized Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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