Document Detail

Physiology and clinical implications of variability of cardiovascular parameters with focus on heart rate and blood pressure.
MedLine Citation:
PMID:  8166052     Owner:  NLM     Status:  MEDLINE    
Power spectral analysis of heart period (R-R) and arterial pressure short-term variability reveals the existence of two rhythmic oscillations: a high frequency (HF) component corresponding to respiratory activity (around 0.25 Hz) and a low frequency (LF) component corresponding to vasomotor waves (around 0.10 Hz). Further, a very low frequency (VLF) component, with a center frequency around 0 Hz, can be identified. It is generally accepted that the power of the HF component of R-R variability is a marker of vagal activity to the sinoatrial node. We have introduced the hypothesis, which is becoming progressively accepted, that the LF component of R-R variability is a marker of sympathetic modulation of the sinoatrial node, whereas the LF component of arterial pressure variability is a marker of sympathetic modulation of vasomotor tone. Moreover, we have suggested that the evaluation (in normalized units) of the LF and HF components of R-R variability (or the LF/HF ratio) can assess the state of the sympatho-vagal balance modulating the sino-atrial node in numerous physiologic and physiopathologic conditions. A large body of evidence has been gathered on the basis of multiple recordings of cardiovascular signals obtained in humans and in acute and chronic animal experiments in favor of this hypothesis.
A Malliani; M Pagani; F Lombardi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  73     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3C-9C     Citation Subset:  AIM; IM    
Ospedale L. Sacco, Milano, Italy.
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MeSH Terms
Blood Pressure / physiology*
Heart Rate / physiology*
Reference Values
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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