Document Detail


Physiology of breathing and respiratory control during sleep.
MedLine Citation:
PMID:  16052413     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies of respiratory control during sleep have revealed that multiple sites of central CO (2) chemosensitivity exist within the brainstem, and different chemosensory sites may function only during certain sleep states. In general, chemical control of respiratory function, related to both hypercapnia and hypoxia, appears to be blunted during sleep. The decline in respiratory activity during sleep is particularly marked in the muscles of the upper airway. A variety of neuromechanical factors originating in the lungs, chest wall, and upper airway also modify respiratory function during sleep. Cardiorespiratory function seems to be less stable during sleep, and arousal responses represent a final element in the control system that preserves cardiorespiratory function by terminating the sleep state and restoring more effective control mechanisms.
Authors:
William R Krimsky; James C Leiter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in respiratory and critical care medicine     Volume:  26     ISSN:  1069-3424     ISO Abbreviation:  Semin Respir Crit Care Med     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-07-29     Completed Date:  2005-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9431858     Medline TA:  Semin Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-12     Citation Subset:  IM    
Affiliation:
Department of Medicine, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA.
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MeSH Terms
Descriptor/Qualifier:
Anoxia / physiopathology
Chemoreceptor Cells / physiology
Humans
Hypercapnia / physiopathology
Pulmonary Gas Exchange / physiology*
Reflex / physiology
Respiratory Mechanics / physiology*
Sleep Apnea, Obstructive / physiopathology*
Sleep Stages / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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