| Physiology of aging related to outcome in the adult respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 2246169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty-nine patients with adult respiratory distress syndrome (ARDS) were enrolled in a study to identify potential age-related changes in organ system function that may help explain the apparent association between age and poor outcome in these patients. Criteria for enrollment included an arterial PO2-to-inspired O2 concentration ratio less than or equal to 200 in a clinical setting consistent with ARDS. Patients were excluded if they were less than 18 yr old, had clinical manifestations of congestive heart failure, were seropositive for the human immunodeficiency virus, or had stage II metastatic lung cancer. Patients were divided into two groups: those less than 60 yr old (mean 42 +/- 3 yr, n = 17) and those greater than or equal to 60 yr old (73 +/- 2 yr, n = 16). A group of six patients was analyzed as a separate subset based on a body temperature less than or equal to 97.5 degrees F at enrollment (hypothermic patients, 73 +/- 4 yr old). Sepsis was present in 67% of the nonhypothermic patients and in all the hypothermic patients. Mortality rates were 12% in the patients less than 60 yr and 69% in the nonhypothermic patients greater than or equal to 60 yr. All the hypothermic patients died. Sequential data obtained over 6 days were compared within and between groups. The following results were obtained. 1) The ratio of arterial PO2 to inspired O2 fraction was greater and the positive end-expiratory pressure used was significantly less in the patients greater than or equal to 60 yr old compared with the younger group.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M H Gee; J E Gottlieb; K H Albertine; J M Kubis; S P Peters; J E Fish |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 69 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1991-01-08 Completed Date: 1991-01-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 822-9 Citation Subset: IM; X |
Affiliation:
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Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Blood Cell Count Blood Pressure / physiology Blood Urea Nitrogen Body Temperature / physiology Cardiac Output / physiology Creatinine / blood Female Hemodynamics / physiology Humans Hypothermia / physiopathology Kidney / physiopathology Male Middle Aged Pulmonary Gas Exchange Respiratory Distress Syndrome, Adult / mortality, physiopathology* Water-Electrolyte Balance |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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