Document Detail

Physiology of MPTP tremor.
MedLine Citation:
PMID:  9827591     Owner:  NLM     Status:  MEDLINE    
Rhesus and vervet monkeys respond differently to treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride neurotoxin (MPTP). Both species develop akinesia, rigidity, and severe postural instability. However, rhesus monkeys only develop infrequent, short episodes of high-frequency tremor, whereas vervet monkeys have many prolonged episodes of low-frequency tremor. After MPTP treatment, the spiking activity of many pallidal neurons became oscillatory and highly correlated. Oscillatory autocorrelation functions were dominated by lower frequencies, cross-correlograms by higher frequencies. The phase shift distribution of the oscillatory cross-correlograms of pallidal cells in MPTP-treated vervet monkey were clustered around 0 phase shift, unlike the oscillatory correlograms in the MPTP-treated rhesus monkey, which were widely distributed between 0 degrees and 180 degrees. Analysis of the instantaneous phase differences between tremors of two limbs in the MPTP monkeys and human parkinsonian patients showed short periods of tremor synchronization. We thus concluded that the rhesus and the vervet models of MPTP-induced parkinsonism may represent the tremulous and nontremulous variants of human parkinsonism. We suggest that the tremor phenomena of Parkinson's disease (PD) are related to the emergence of synchronous neuronal oscillations in the basal ganglia. Finally, the oscillating neuronal assemblies in the pallidum of tremulous parkinsonian primates are more stable (in time and in space) than those of parkinsonian primates without overt tremor.
H Bergman; A Raz; A Feingold; A Nini; I Nelken; D Hansel; H Ben-Pazi; A Reches
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  13 Suppl 3     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1998  
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Department of Physiology and the Center for Neural Computation, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / therapeutic use*
Cercopithecus aethiops
Dopamine Agents / therapeutic use*
Macaca mulatta
Tremor / drug therapy*
Reg. No./Substance:
0/Dopamine Agents; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

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