Document Detail


Physiological and symptomatic responses to postural change in non-diabetic subjects during hypoglycaemia.
MedLine Citation:
PMID:  7924164     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Insulin-induced hypoglycaemia is characterized by an autonomic disturbance which produces some of the symptoms of hypoglycaemia. How an additional autonomic stress like postural change may alter physiological responses and symptoms of hypoglycaemia is not known. In 10 healthy male subjects (mean age 24 years) we observed physiological and symptomatic responses to postural change during acute (20 min) and prolonged (60 min) hyperinsulinaemic (60 m-units min-1 m-2) hypoglycaemia (2.5 mmol/l) and euglycaemia (4.5 mmol/l), and placebo control (saline). 2. In all studies standing increased plasma catecholamines (adrenaline, P < 0.001; noradrenaline, P < 0.0001), blood pressure (P < 0.0001) and heart rate (P < 0.0001). Catecholamine responses to standing were augmented by acute hypoglycaemia (adrenaline, P < 0.005; noradrenaline, P < 0.01), but less so by prolonged hypoglycaemia (adrenaline, P < 0.05; noradrenaline, P < 0.05). Supine heart rate was higher before standing during prolonged hypoglycaemia (P < 0.05), but did not increase as much on standing when compared with acute hypoglycaemia and prolonged euglycaemia. 3. During acute hypoglycaemia, autonomic symptoms increased on standing, but during prolonged hypoglycaemia, in the presence of generally higher symptom scores, standing had no effect. Autonomic symptoms, with the exception of hunger, tended to decrease with time (P < 0.05) during prolonged hypoglycaemia. 4. To conclude, posture does modify the catecholamine and symptomatic responses to hypoglycaemia, but this effect is dependent on the duration of hypoglycaemia. Hypoglycaemia and hyperinsulinaemia had little or no effect on the cardiovascular responses to changing posture.
Authors:
D G Maggs; I A MacDonald
Related Documents :
23169864 - Outcome quality of in-patient cardiac rehabilitation in elderly patients - identificati...
902154 - Reduction of intrinsic sinoatrial frequency and norepinephrine response of the exercise...
11474344 - Heart rate variability in athletes: relationship with central and peripheral performance.
8477674 - Autonomic nervous control of heart rate during blood-flow restricted exercise in man.
24149454 - Lung diffusion capacity can predict maximal exercise in apparently healthy heavy smokers.
23055024 - Peroxiredoxins and sports: new insights on the antioxidative defense.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  87     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-10-31     Completed Date:  1994-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM; S    
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham, Queens Medical Centre, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Blood Glucose / metabolism
Blood Pressure / physiology
Catecholamines / blood*
Epinephrine / blood
Heart Rate / physiology
Humans
Hypoglycemia / blood,  physiopathology*
Insulin / diagnostic use
Male
Norepinephrine / blood
Posture / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 11061-68-0/Insulin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physical fitness and insulin sensitivity in human subjects with a low insulin response to glucose.
Next Document:  Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in...