Document Detail


Physiological studies on vasoactive intestinal peptide in rat small bowel isografts.
MedLine Citation:
PMID:  15050161     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Vasoactive intestinal peptide (VIP) is released by stimulation of nonadrenergic noncholinergic (NANC) inhibitory nerves. In order to evaluate the function of VIP in jejunal isografts, we examined the enteric nerve responses in isografted rat jejunum compared with normal jejunum. METHODS: Orthotopic entire small bowel transplantation (SBT) with portocaval drainage was performed from Lewis rats to Lewis rats. Grafted tissue specimens were obtained 130 days after SBT (n = 8). As controls, normal segments of the jejunum were obtained from nontransplanted Lewis rats (n = 20). A mechanograph was used to evaluate in vitro jejunal responses to electrical field stimulation (EFS) of the adrenergic and cholinergic nerves before and after treatment with various autonomic nerve blockers and VIP. RESULTS: The isografted jejunum was more strongly innervated by excitatory nerves, especially NANC excitatory nerves, than the normal jejunum (P <.05). VIP mediated relaxation reactions of NANC inhibitory nerves in the normal but to a lesser extent in the isografted jejunum (P <.05). CONCLUSIONS: The increased NANC excitatory nerves and the decreased effects of VIP in mediating NANC inhibitory nerves may largely relate to the peristaltic abnormalities seen in the isografted LEW rat jejunum.
Authors:
R Tomita; S Fujisaki; E Park; K Kimizuka; T Ikede; T Koshinaga; M Shibata; K Tanjoh
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  36     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  367-9     Citation Subset:  IM    
Affiliation:
First Department of Surgery, Nihon University School of Medicine, Tokyo, Japan. rtomita-ndus@mvg.biglobe.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Intestine, Small / physiology,  transplantation*
Jejunum / physiology,  transplantation
Peristalsis / physiology
Rats
Rats, Inbred Lew
Transplantation, Isogeneic / methods,  physiology*
Vasoactive Intestinal Peptide / metabolism*
Chemical
Reg. No./Substance:
37221-79-7/Vasoactive Intestinal Peptide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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