Document Detail

Physiological significance of volume-regulatory transporters.
MedLine Citation:
PMID:  10329946     Owner:  NLM     Status:  MEDLINE    
Research over the past 25 years has identified specific ion transporters and channels that are activated by acute changes in cell volume and that serve to restore steady-state volume. The mechanism by which cells sense changes in cell volume and activate the appropriate transporters remains a mystery, but recent studies are providing important clues. A curious aspect of volume regulation in mammalian cells is that it is often absent or incomplete in anisosmotic media, whereas complete volume regulation is observed with isosmotic shrinkage and swelling. The basis for this may lie in an important role of intracellular Cl- in controlling volume-regulatory transporters. This is physiologically relevant, since the principal threat to cell volume in vivo is not changes in extracellular osmolarity but rather changes in the cellular content of osmotically active molecules. Volume-regulatory transporters are also closely linked to cell growth and metabolism, producing requisite changes in cell volume that may also signal subsequent growth and metabolic events. Thus, despite the relatively constant osmolarity in mammals, volume-regulatory transporters have important roles in mammalian physiology.
W C O'Neill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of physiology     Volume:  276     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-07     Completed Date:  1999-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  C995-C1011     Citation Subset:  IM    
Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
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MeSH Terms
Carrier Proteins / physiology*
Cell Size / physiology*
Ion Transport*
Osmolar Concentration
Sodium-Hydrogen Antiporter / physiology
Sodium-Potassium-Chloride Symporters
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Sodium-Hydrogen Antiporter; 0/Sodium-Potassium-Chloride Symporters

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