Document Detail

Physiological significance of benzo(alpha)pyrene adsorbed to carbon blacks: elution studies, AHH determinations.
MedLine Citation:
PMID:  6264776     Owner:  NLM     Status:  MEDLINE    
Desorption of benzo(alpha)pyrene from commercial carbon blacks by tissue fluids in vitro is compared to arylhydrocarbon hydroxylase induction in mice at three levels of carbon black exposure. Less than 0.005% of the adsorbed benzo(alpha)pyrene content determined by soxhlet extraction in toluene is eluted by human plasma, swine serum, swine lung homogenate and swine lung washings. Statistically significant differences in elution efficiency are observed by the various tissue fluids and carbon blacks. There is no detectable increase in AHH level in mouse lung or liver tissues even at the highest carbon black exposure and consumption rate of 1g/g bdywt/year.
F Buddingh; M J Bailey; B Wells; J Haesemeyer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  American Industrial Hygiene Association journal     Volume:  42     ISSN:  0002-8894     ISO Abbreviation:  Am Ind Hyg Assoc J     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0371160     Medline TA:  Am Ind Hyg Assoc J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  503-9     Citation Subset:  IM    
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MeSH Terms
Aryl Hydrocarbon Hydroxylases / metabolism*
Benzopyrenes / pharmacology*
Carbon / pharmacology*
Enzyme Induction
Reg. No./Substance:
0/Benzopyrenes; 50-32-8/Benzo(a)pyrene; 7440-44-0/Carbon; EC Hydrocarbon Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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