| Physiological role of nitric oxide in oxygen consumption by arteriolar wall. | |
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MedLine Citation:
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PMID: 19162927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the role of nitric oxide (NO) in regulating oxygen consumption by vessel walls, the oxygen consumption rate of arteriolar walls in rat cremaster muscle was measured in vivo during flow-induced vasodilation and after inhibiting NO synthesis. The oxygen consumption rate of arteriolar walls was calculated based on the intra- and peri-vascular oxygen tension (PO(2)) values measured by phosphorescence quenching laser microscopy. The peri-vascular PO(2) value of the arterioles during vasodilation was significantly higher than under control conditions, although the intravascular PO(2) values under both conditions were approximately the same. On the other hand, inhibition of NO synthesis caused a significant decrease in both the intra- and peri-vascular PO(2) values of the arterioles. The inhibition of NO synthesis increased the oxygen consumption rate of the vessel walls by 42%, whereas enhancement of flow-induced NO release decreased it by 34%. These results suggest that NO plays an important role not only as a regulator of peripheral vascular tone, but also as a modulator of tissue oxygen consumption by reducing oxygen consumption by vessel walls. |
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Authors:
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Masahiro Shibata; Takehiro Yamakoshi; Ken-Ichi Yamakoshi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 2008 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2008 |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2009-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 1389-92 Citation Subset: IM |
Affiliation:
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Department Bioscience and Engineering, Shibaura Institute of Technology, Saitama, Japan. shibatam@sic.shibaura-it.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / drug effects, metabolism, physiology* Endothelium, Vascular / drug effects, metabolism, physiology* Muscle, Skeletal / blood supply, drug effects, physiology NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / antagonists & inhibitors, physiology* Nitric Oxide Synthase / antagonists & inhibitors Oxygen / physiology Oxygen Consumption / physiology* Rats Rats, Wistar Vasodilation / drug effects |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 7782-44-7/Oxygen; EC 1.14.13.39/Nitric Oxide Synthase |
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