Document Detail


Physiological response to the six-minute walk test in pulmonary arterial hypertension.
MedLine Citation:
PMID:  16204599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 6-min walk test (6MWT) is commonly used to evaluate exercise capacity in patients with pulmonary arterial hypertension (PAH). However, little is known about the corresponding metabolic stress as measured by cardiopulmonary exercise testing. The present study, therefore, measured ventilatory variables and heart rate during the 6MWT and symptom-limited incremental maximal exercise testing in 20 patients with PAH. The distance walked in 6 min was 450+/-22 m (mean+/-se). During the 6MWT, ventilation, O2 consumption, CO2 production and heart rate increased during the first 3-4 min, and then remained stable. As compared with the maximum values measured during the cardiopulmonary exercise test, O2 consumption tended to be higher (14.2+/-0.6 versus 12.9+/-0.7 mL.kg-1.min-1), while maximum ventilation (46+/-3 versus 57+/-4 L.min-1), respiratory quotient (0.90+/-0.02 versus 1.15+/-0.02) and heart rate (119+/-4 versus 135+/-4 beats.min-1) remained lower. In conclusion, patients with pulmonary arterial hypertension exercise at higher aerobic capacity and lower metabolic stress during the 6MWT than during a cardiopulmonary exercise test.
Authors:
G Deboeck; G Niset; J-L Vachiery; J-J Moraine; R Naeije
Related Documents :
8262699 - Influence of exercise intensity and duration on post-exercise pulmonary diffusion capac...
14565689 - Pulmonary hemodynamics in obstructive sleep apnea: frequency and causes of pulmonary hy...
19487219 - Pulmonary arterial hypertension: the most devastating vascular complication of systemic...
15888849 - Fade of pulmonary function during residual neuromuscular blockade.
12952269 - Bosentan treatment in patients with primary pulmonary hypertension receiving nonparente...
12935729 - Immunohistochemical investigation of pulmonary surfactant-associated protein a in fire ...
8872669 - Lung mechanics during induced bronchoconstriction.
16996799 - Respiratory and cardiovascular functions among smoking and nonsmoking girls from two re...
12959299 - Stress responses after treatment of hypercholesterolaemia with simvastatin.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  26     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2006-04-04     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  667-72     Citation Subset:  IM    
Affiliation:
Department of Physiology, Erasme Hospital, and Department of Physiology, Institute of Sports and Physiotherapy, Free University of Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Exercise Test / methods*
Exercise Tolerance / physiology*
Female
Heart Rate / physiology
Humans
Hypertension, Pulmonary / metabolism,  physiopathology*
Male
Middle Aged
Oxygen Consumption
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology
Stress, Physiological / metabolism,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A possible role for Epstein-Barr virus in the pathogenesis of pleural effusion.
Next Document:  Tumour necrosis factor-alpha (-308) gene polymorphism in obstructive sleep apnoea-hypopnoea syndrome...