Document Detail

Physiological response to the six-minute walk test in pulmonary arterial hypertension.
MedLine Citation:
PMID:  16204599     Owner:  NLM     Status:  MEDLINE    
The 6-min walk test (6MWT) is commonly used to evaluate exercise capacity in patients with pulmonary arterial hypertension (PAH). However, little is known about the corresponding metabolic stress as measured by cardiopulmonary exercise testing. The present study, therefore, measured ventilatory variables and heart rate during the 6MWT and symptom-limited incremental maximal exercise testing in 20 patients with PAH. The distance walked in 6 min was 450+/-22 m (mean+/-se). During the 6MWT, ventilation, O2 consumption, CO2 production and heart rate increased during the first 3-4 min, and then remained stable. As compared with the maximum values measured during the cardiopulmonary exercise test, O2 consumption tended to be higher (14.2+/-0.6 versus 12.9+/-0.7, while maximum ventilation (46+/-3 versus 57+/-4 L.min-1), respiratory quotient (0.90+/-0.02 versus 1.15+/-0.02) and heart rate (119+/-4 versus 135+/-4 beats.min-1) remained lower. In conclusion, patients with pulmonary arterial hypertension exercise at higher aerobic capacity and lower metabolic stress during the 6MWT than during a cardiopulmonary exercise test.
G Deboeck; G Niset; J-L Vachiery; J-J Moraine; R Naeije
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  26     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2006-04-04     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  667-72     Citation Subset:  IM    
Department of Physiology, Erasme Hospital, and Department of Physiology, Institute of Sports and Physiotherapy, Free University of Brussels, Belgium.
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MeSH Terms
Exercise Test / methods*
Exercise Tolerance / physiology*
Heart Rate / physiology
Hypertension, Pulmonary / metabolism,  physiopathology*
Middle Aged
Oxygen Consumption
Pulmonary Gas Exchange / physiology
Pulmonary Ventilation / physiology
Stress, Physiological / metabolism,  physiopathology

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