Document Detail

Physiological regulation in cigarette exposed infants: an examination of potential moderators.
MedLine Citation:
PMID:  21798345     Owner:  NLM     Status:  MEDLINE    
The primary purpose of this study was to examine pathways from prenatal cigarette exposure to physiological regulation at 2 months of age. Specifically, we explored the possibility that any association between prenatal cigarette exposure and infant physiological regulation was moderated by fetal growth, prenatal or postnatal environmental tobacco smoke (ETS) exposure or maternal depressive symptomatology during pregnancy. We evaluated whether exposed infants who were also exposed to ETS after birth, were small for gestational age (SGA) or had mothers with higher depressive symptoms during pregnancy had the highest levels of physiological dysregulation. Respiratory sinus arrhythmia (RSA) was obtained from 234 (166 exposed and 68 nonexposed) infants during sleep. As expected, cigarette-exposed infants had significantly lower RSA than nonexposed infants. This association was not moderated by prenatal or postnatal ETS exposure, or maternal depressive symptomatology during pregnancy. However, small for gestational age status did moderate this association such that nonexposed infants who were not small for gestational age had a significantly higher RSA than nonexposed small for gestational age infants and exposed infants. These findings provide additional evidence that prenatal cigarette exposure is directly associated with dysregulation during infancy.
Pamela Schuetze; Rina D Eiden; Craig R Colder; Theresa R Gray; Marilyn A Huestis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2011-07-21
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  33     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-29     Completed Date:  2012-01-31     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Depression / complications,  physiopathology
Heart Rate / physiology*
Infant, Newborn
Infant, Small for Gestational Age / physiology
Pregnancy Complications / physiopathology,  psychology*
Prenatal Exposure Delayed Effects / physiopathology*,  psychology
Smoking / adverse effects*,  physiopathology*
Tobacco Smoke Pollution / adverse effects*
Grant Support
1 R01 DA019632-01/DA/NIDA NIH HHS; R01 DA019632/DA/NIDA NIH HHS; R01 DA019632-02/DA/NIDA NIH HHS
Reg. No./Substance:
0/Tobacco Smoke Pollution

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