Document Detail

Physiological purkinje cell death is spatiotemporally organized in the developing mouse cerebellum.
MedLine Citation:
PMID:  19238501     Owner:  NLM     Status:  MEDLINE    
Physiological cell death is crucial for matching defined cellular populations within the central nervous system. Whereas the time course of developmental cell death in the central nervous system is well analyzed, information about its precise spatial patterning is scarce. Yet, the latter one is needed to appraise its contribution to circuit formation and refinement. Here, we document that during normal cerebellar development, dying Purkinje cells were highly localized within the vermal midline and in a lobule specific, parasagittal pattern along the whole mediolateral axis. In addition, single hot spots of cell death localized to the caudal declive and ventral lobule IX within the posterolateral fissure. These hot spots of dying Purkinje cells partly overlapped with gaps within the Purkinje cell layer which supports the classification of different gaps based on histological and molecular criteria, i.e., midline gap, patchy gaps, and raphes. Areas characterized by a high incidence of Purkinje cell death and gaps colocalize with known molecular and functional boundaries within the cerebellar cortex. Physiological cell death can thus be considered to serve as an important regulator of cerebellar histogenesis.
Jakob Jankowski; Andreas Miething; Karl Schilling; Stephan L Baader
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-24
Journal Detail:
Title:  Cerebellum (London, England)     Volume:  8     ISSN:  1473-4230     ISO Abbreviation:  Cerebellum     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-28     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101089443     Medline TA:  Cerebellum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-90     Citation Subset:  IM    
Institute of Anatomy, Anatomy and Cell Biology, University of Bonn, 53115 Bonn, Germany.
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MeSH Terms
Animals, Newborn
Cell Death / physiology
Cell Movement
Cerebellum / cytology*,  growth & development*
Gene Expression Regulation, Developmental / physiology*
Mice, Inbred C57BL
Microscopy, Electron, Transmission / methods
Nerve Tissue Proteins / metabolism
Purkinje Cells / physiology*,  ultrastructure
Time Factors
Reg. No./Substance:
0/Nerve Tissue Proteins

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