| Physiological properties of direction-selective ganglion cells in early postnatal and adult mouse retina. | |
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MedLine Citation:
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PMID: 19103682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selective responses of retinal ganglion cells (RGCs) to the direction of motion have been recorded extracellularly from the rabbit and the mouse retina at eye opening. Recently, it has been shown that the development of this circuitry is light independent. Using whole-cell patch clamp recording, we report here that mouse early postnatal direction-selective ganglion cells (DSGCs) showed lower membrane excitability, lower reliability of synaptic transmission and much slower kinetics of light responses compared with adult DSGCs. However, the degree of direction selectivity of early postnatal DSGCs measured by the direction-selective index and the width of the directional tuning curve was almost identical to that of adult DSGCs. The DSGCs exhibited a clear selectivity for the direction of motion at the onset of light sensitivity. Furthermore, the degree of direction selectivity was not affected by rearing in complete darkness from birth to postnatal day 11 or 30. The formation of the retinal neurocircuitry for coding motion direction is completely independent of light. |
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Authors:
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Minggang Chen; Shijun Weng; Qiudong Deng; Zhen Xu; Shigang He |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-22 |
Journal Detail:
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Title: The Journal of physiology Volume: 587 ISSN: 1469-7793 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-16 Completed Date: 2009-12-07 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: England |
Other Details:
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Languages: eng Pagination: 819-28 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Age Factors Animals Animals, Newborn Mice Mice, Inbred C57BL Nerve Net / cytology, growth & development Photic Stimulation / methods Retina / cytology, growth & development Retinal Ganglion Cells / cytology*, physiology* Visual Pathways / cytology, growth & development |
| Comments/Corrections | |
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