Document Detail

Physiological predictors of maximum treadmill walking performance in patients with intermittent claudication.
MedLine Citation:
PMID:  19214940     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to identify physiological predictors of maximum treadmill walking performance (MWD) in patients with intermittent claudication. Forty-five claudicants performed a graded treadmill test to determine MWD, peak oxygen uptake, and gas exchange threshold. Calf muscle oxygenation (StO (2)) at 1 min and time to minimum StO (2) were also measured using near-infrared spectroscopy. On other occasions, peak calf blood flow, resting ankle-brachial index, and pulmonary oxygen uptake kinetics during steady-state walking were assessed. A forward stepwise multiple regression analysis was performed to determine predictors of MWD. A regression model comprising time to minimum StO (2), peak oxygen uptake, and StO (2) at 1 min explained 64% of the variation in MWD. The results suggest that cardiopulmonary fitness and the ability to match oxygen delivery to metabolic demand are important determinants of walking performance in claudicants, and that certain near-infrared spectroscopy variables might be useful in studies that evaluate the mechanisms of clinical improvement with different treatment interventions.
G A Tew; S Nawaz; M Blagojevic; I Zwierska; J M Saxton
Publication Detail:
Type:  Journal Article     Date:  2009-02-12
Journal Detail:
Title:  International journal of sports medicine     Volume:  30     ISSN:  1439-3964     ISO Abbreviation:  Int J Sports Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  467-72     Citation Subset:  IM    
Centre for Sport and Exercise Science, Sheffield Hallam University, United Kingdom.
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MeSH Terms
Ankle Brachial Index
Exercise Test / methods
Exercise Tolerance
Intermittent Claudication / physiopathology*
Leg / blood supply
Middle Aged
Oxygen Consumption*
Pulmonary Gas Exchange
Regression Analysis
Spectroscopy, Near-Infrared / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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