Document Detail

Physiological and pharmacological studies on nematodes.
MedLine Citation:
PMID:  11034163     Owner:  NLM     Status:  MEDLINE    
Classical transmitters and neuroactive peptides act as transmitters or modulators within the central and peripheral nervous systems of nematodes, for example Ascaris suum and Caenorhabditis elegans. Acetylcholine (ACh) and gamma-aminobutyric acid (GABA) are respectively the excitatory and inhibitory transmitters onto somatic body wall muscle while 5-hydroxytrypamine (5-HT) is the excitatory transmitter onto pharyngeal muscle. 5-HT also reduces ACh-induced contractions of somatic muscle and this action of 5-HT is mediated through activation of adenylate cyclase while that on pharyngeal muscle is mediated through inositol phosphate activation. Glutamate, dopamine and octopamine also have transmitter roles in nematodes. Neuroactive peptides of the RFamide family can excite somatic muscle, for example, AF-1 (KNEFIRFamide), AF-2 (KHEYLRFamide), AF-3 (AVPGVLRFamide) and AF-4 (GDVPGVLRFamide) or inhibit and relax this muscle, for example, PF-1 (SDPNFLRFamide), PF-2 (SADPNFLRFamide) and PF-4 (KPNlRFamide). In addition PF-3 (AF-8) (KSAYMRFamide) has a biphasic action on pharyngeal muscle, excitation followed by inhibition while AF-1 only inhibits this muscle. The peptide effects can be either pre- or postsynaptic or both and are likely to be mediated through second messenger systems. In addition these peptides modulate the action of classical transmitters, particularly ACh.
R J Walker; C J Franks; D Pemberton; C Rogers; L Holden-Dye
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biologica Hungarica     Volume:  51     ISSN:  0236-5383     ISO Abbreviation:  Acta. Biol. Hung.     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-13     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8404358     Medline TA:  Acta Biol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  379-94     Citation Subset:  IM    
Department of Physiology and Pharmacology, School of Biological Sciences, University of Southampton, UK.
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MeSH Terms
Acetylcholine / pharmacology,  physiology
Amino Acid Sequence
Ascaridia / drug effects,  physiology
Ascaris / drug effects,  physiology
Caenorhabditis elegans / drug effects,  physiology
Dopamine / pharmacology,  physiology
Glutamic Acid / pharmacology,  physiology
Nematoda / drug effects*,  physiology*
Neuropeptides / chemistry,  pharmacology*,  physiology*
Serotonin / pharmacology,  physiology
gamma-Aminobutyric Acid / pharmacology,  physiology
Reg. No./Substance:
0/Neuropeptides; 50-67-9/Serotonin; 51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 56-86-0/Glutamic Acid

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