Document Detail


Physiological perfusion model for cephalosporin antibiotics I: Model selection based on blood drug concentrations.
MedLine Citation:
PMID:  621635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various cephalosporins with different degrees of protein binding were administered to human volunteers. Blood samples were collected as a function of time and were assayed for drug content by a microbiological assay. A pharmacokinetic analysis of the data was performed using a two-compartment model with and without protein binding in the central compartment and a perfusion model. Both the two-compartment model without protein binding and the physiological perfusion model adequately described the blood levels of all three cephalosporins.
Authors:
D S Greene; R Quintiliani; C H Nightingale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  67     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / metabolism
Cephalosporins / blood*
Humans
Kinetics
Models, Biological
Perfusion
Protein Binding
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Cephalosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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