Document Detail


Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles.
MedLine Citation:
PMID:  22795858     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO(2) nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to catastrophic effect on cell physiology. Such damage becomes nontrivial only in the absence of p53 gene, which regulates cells' anti-oxidation and detoxification. This genotoxic effect is absent in cells treated with amorphous SiO(2) NPs.
Authors:
Zhiqin Chu; Yuanjie Huang; Lili Li; Qian Tao; Quan Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-13
Journal Detail:
Title:  Biomaterials     Volume:  -     ISSN:  1878-5905     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Physics, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong.
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