Document Detail

Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles.
MedLine Citation:
PMID:  22795858     Owner:  NLM     Status:  Publisher    
We disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO(2) nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to catastrophic effect on cell physiology. Such damage becomes nontrivial only in the absence of p53 gene, which regulates cells' anti-oxidation and detoxification. This genotoxic effect is absent in cells treated with amorphous SiO(2) NPs.
Zhiqin Chu; Yuanjie Huang; Lili Li; Qian Tao; Quan Li
Related Documents :
2015798 - Apical cell shape changes during drosophila imaginal leg disc elongation: a novel morph...
8145818 - Compartment boundaries and the control of drosophila limb pattern by hedgehog protein.
16820778 - Exploring the regulation of human neural precursor cell differentiation using arrays of...
9272958 - Concentration-dependent patterning of the xenopus ectoderm by bmp4 and its signal trans...
24758408 - Epidermal growth factor receptor signalling in human breast cancer cells operates paral...
2606788 - Primordial germ cells and gonadal development in the golden hamster.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-13
Journal Detail:
Title:  Biomaterials     Volume:  -     ISSN:  1878-5905     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Physics, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regeneration of peripheral nerves by transplanted sphere of human mesenchymal stem cells derived fro...
Next Document:  In-vivo performance of high-density collagen gel tubes for urethral regeneration in a rabbit model.