Document Detail


Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure.
MedLine Citation:
PMID:  8887252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood pressure regulation is an integrated physiological phenomenon known to be influenced by many biological processes and by a variety of environmental factors. Epidemiological studies nevertheless suggest that up to 30% of the variation in blood pressure could be due to genetic factors. Thus, mutations in genes that control blood pressure may be the underlying cause of essential hypertension. Arterial blood pressure is critically dependent on the sodium balance and the regulation of renal sodium excretion is one of the most important homeostatic functions of the body. The identification of genes encoding proteins that transport Na+ across cells of the kidney tubules and of those regulating the activity of these sodium-transporting proteins will therefore bring further insights into the pathophysiology of salt-sensitive hypertension.
Authors:
E Hummler; B C Rossier
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  19     ISSN:  1420-4096     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Affiliation:
Institut de Pharmacologie et de Toxicologie, Université, Lausanne, Suisse.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology*
Carrier Proteins / genetics,  metabolism
Epithelium / physiology,  physiopathology
Humans
Hypertension / etiology,  physiopathology*
Ion Transport
Kidney Tubules / physiology*,  physiopathology
Point Mutation
Sodium Channels / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Sodium Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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