Document Detail


Physiological and pathological functions of acid-sensing ion channels in the central nervous system.
MedLine Citation:
PMID:  22204324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protons are important signals for neuronal function. In the central nervous system (CNS), proton concentrations change locally when synaptic vesicles release their acidic contents into the synaptic cleft, and globally in ischemia, seizures, traumatic brain injury, and other neurological disorders due to lactic acid accumulation. The finding that protons gate a distinct family of ion channels, the acid-sensing ion channels (ASICs), has shed new light on the mechanism of acid signaling and acidosis-associated neuronal injury. Accumulating evidence has suggested that ASICs play important roles in physiological processes such as synaptic plasticity, learning/memory, fear conditioning, and retinal integrity, and in pathological conditions such as brain ischemia, multiple sclerosis, epileptic seizures, and malignant glioma. Thus, targeting these channels may lead to novel therapeutic interventions for neurological disorders. The goal of this review is to provide an update on recent advances in our understanding of the functions of ASICs in the CNS.
Authors:
Xiang-Ping Chu; Zhi-Gang Xiong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current drug targets     Volume:  13     ISSN:  1873-5592     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-09-05     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Affiliation:
Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA. chux@umkc.edu
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MeSH Terms
Descriptor/Qualifier:
Acid Sensing Ion Channels
Animals
Central Nervous System / metabolism*,  pathology*
Humans
Nerve Tissue Proteins / metabolism*
Neurons / metabolism*,  pathology*
Protons
Sodium Channels / metabolism*
Grant Support
ID/Acronym/Agency:
R01 NS047506/NS/NINDS NIH HHS; R01 NS049470/NS/NINDS NIH HHS; R01NS47506/NS/NINDS NIH HHS; R01NS49470/NS/NINDS NIH HHS; R56 NS047506/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Acid Sensing Ion Channels; 0/Nerve Tissue Proteins; 0/Protons; 0/Sodium Channels
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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