Document Detail

Physiological parameters governing the action of pancreatic lipase.
MedLine Citation:
PMID:  20193096     Owner:  NLM     Status:  MEDLINE    
The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the action of pancreatic lipase under the range of physiological conditions that occur within the human small intestine, and the literature that does exist is often contradictory. Due to the importance of pancreatic lipase activity to nutrition and weight management, the present review aims to assess the current body of knowledge with regards to the physiology behind the action of this unique gastrointestinal enzyme system. Existing data would suggest that pancreatic lipase activity is affected by intestinal pH, the presence of colipase and bile salts, but not by the physiological range of Ca ion concentration (as is commonly assumed). The control of secretion of pancreatic lipase and its associated factors appears to be driven by gastrointestinal luminal content, particularly the presence of acid or digested proteins and fats in the duodenal lumen. Secretion of colipase, bile acids and pancreatic lipase is driven by cholecystokinin and secretin release.
Iain A Brownlee; Deborah J Forster; Matthew D Wilcox; Peter W Dettmar; Chris J Seal; Jeff P Pearson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-01
Journal Detail:
Title:  Nutrition research reviews     Volume:  23     ISSN:  1475-2700     ISO Abbreviation:  Nutr Res Rev     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9113797     Medline TA:  Nutr Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-54     Citation Subset:  IM    
Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, UK.
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MeSH Terms
Bile Acids and Salts / pharmacology
Calcium / physiology
Cholecystokinin / physiology
Colipases / physiology
Digestion / physiology*
Enzyme Inhibitors / pharmacology
Hydrogen-Ion Concentration
Intestinal Absorption / drug effects
Intestine, Small / chemistry,  physiology
Intestines / chemistry,  metabolism
Lactones / pharmacology
Lipase / antagonists & inhibitors,  metabolism*,  secretion
Lipid Metabolism / physiology*
Pancreas / enzymology*
Secretin / physiology
Grant Support
BB/G00563X/1//Biotechnology and Biological Sciences Research Council; BBS/S/M/2006/13 035//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cations; 0/Colipases; 0/Enzyme Inhibitors; 0/Lactones; 1393-25-5/Secretin; 7440-70-2/Calcium; 9011-97-6/Cholecystokinin; 96829-58-2/orlistat; EC

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