Document Detail


Physiological monitoring of small animals during magnetic resonance imaging.
MedLine Citation:
PMID:  15910980     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maintaining a stable physiologic state is essential when studying animal models of epilepsy with simultaneous electroencephalograph (EEG) and functional magnetic resonance imaging (fMRI) or EEG and magnetic resonance spectroscopy (MRS). To achieve and maintain such stability in rats in the MRI environment, a minimally invasive but comprehensive system was developed to monitor body temperature, heart rate, blood pressure, blood oxygen saturation and end-tidal CO2 (ETCO2) of expired gas. All physiologic parameters were successfully monitored in Sprague-Dawley rats without interfering with EEG recordings during simultaneous fMRI and MRS studies. Body temperature, heart rate, blood pressure, blood oxygen saturation, and ETCO2, were maintained between 36.5 and 37.5 degrees C, 250-450 beats/min, 136+/-17 mmHg, >90%, and 20-35 mmHg, respectively for 6-8 h under inhalational anesthesia. This set-up could be extended to study in vivo applications in other laboratory animals with only minor modifications.
Authors:
Seyed M Mirsattari; Frank Bihari; L Stan Leung; Ravi S Menon; Zheng Wang; John R Ives; Robert Bartha
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-08
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  144     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-24     Completed Date:  2005-08-18     Revised Date:  2008-09-14    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  207-13     Citation Subset:  IM    
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario, 10-OP3, 339 Windermere Rd, London, Ont., Canada, N6A 5A5. smmirsat@uwo.ca
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MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / pharmacology
Animals
Body Temperature / drug effects,  physiology
Brain / anatomy & histology,  physiology
Electroencephalography
Magnetic Resonance Imaging / instrumentation,  methods*
Magnetic Resonance Spectroscopy / instrumentation,  methods*
Male
Monitoring, Physiologic / instrumentation,  methods*
Neurophysiology / instrumentation,  methods*
Rats
Rats, Sprague-Dawley / physiology*
Stereotaxic Techniques
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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