Document Detail

Physiological modulation of the uptake and fate of glucose in brown adipose tissue.
MedLine Citation:
PMID:  8216213     Owner:  NLM     Status:  MEDLINE    
Glucose utilization indices (GUI values) and rates of fatty acid synthesis in interscapular brown adipose tissue (IBAT) varied during the diurnal cycle in virgin and late-pregnant rats permitted unrestricted access to food. In virgin rats, peak GUI values and lipogenic rates were observed at the end of the dark (feeding) phase, but were not sustained during the light phase. Whereas peak GUI values were comparable with those observed during re-feeding after 24 h starvation, maximum rates of IBAT fatty acid synthesis in virgin rats during the diurnal cycle were only approx. 25% of those measured during re-feeding after 24 h starvation. Despite hyperphagia, GUI values during the diurnal cycle in late-pregnant rats fed ad libitum were generally lower than those of age-matched virgin controls. The percentage of pyruvate dehydrogenase complex present in the active form (PDHa) was also significantly decreased. Suppression of GUI and PDHa was not parallelled by suppression of fatty acid synthesis. IBAT GUI values in late-pregnant rats during chow re-feeding ad libitum after 24 h starvation were only 25% of those of corresponding virgin controls, and stimulation of fatty acid synthesis was also dramatically attenuated. The suppression of IBAT GUI values after re-feeding in pregnancy was not due to depletion of GLUT 4 protein. The results are discussed in relation to the importance of glucose as a precursor for fatty acid synthesis in IBAT.
M C Sugden; M J Holness
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  295 ( Pt 1)     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-15     Completed Date:  1993-11-15     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
Department of Biochemistry, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, University of London, U.K.
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MeSH Terms
Adipose Tissue, Brown / metabolism*
Biological Transport
Blood Glucose / analysis
Circadian Rhythm / physiology
Fatty Acids / biosynthesis*
Glucose / metabolism*
Glucose Transporter Type 4
Monosaccharide Transport Proteins / metabolism*
Muscle Proteins*
Nutritional Status / physiology
Pregnancy, Animal / metabolism*
Pyruvate Dehydrogenase Complex / metabolism
Rats, Wistar
Starvation / metabolism
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids; 0/Glucose Transporter Type 4; 0/Monosaccharide Transport Proteins; 0/Muscle Proteins; 0/Pyruvate Dehydrogenase Complex; 0/Slc2a4 protein, rat; 50-99-7/Glucose

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