Document Detail


Physiological mechanisms of focal epileptogenesis.
MedLine Citation:
PMID:  3922749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The key elements in the development of epileptogenesis appear to be the capacity of membranes in some (pacemaker) neurons to develop intrinsic burst discharges, the presence of disinhibition, and the proper excitatory synaptic circuitry. It is likely that the relative role of each of these processes will differ at different sites in the central nervous system which are prone to epileptogenesis. Synchronization of neuronal populations is a vital element in the development of focal discharge and a variety of mechanisms, including those dependent upon excitatory postsynaptic potentials, and other interactions are possible. Pathological processes may alter some or all of these regulatory mechanisms. However, different pathological entities presumably produce epileptogenesis through different combinations of pathogenetic mechanisms.
Authors:
D A Prince
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Epilepsia     Volume:  26 Suppl 1     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-15     Completed Date:  1985-07-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S3-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism,  physiology
Action Potentials
Animals
Brain / metabolism,  pathology,  physiopathology*
Cerebral Cortex / metabolism,  physiopathology
Cortical Synchronization
Dopamine / metabolism,  physiology
Epilepsies, Partial / etiology,  pathology,  physiopathology*
Haplorhini
Hippocampus / metabolism,  physiopathology
Humans
Neural Conduction
Neuronal Plasticity
Neurons / metabolism,  pathology,  physiology
Seizures / etiology,  physiopathology
Serotonin / metabolism,  physiology
Synapses / physiology
Grant Support
ID/Acronym/Agency:
NS 06477/NS/NINDS NIH HHS; NS 12151/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
50-67-9/Serotonin; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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