Document Detail


Physiological measures of therapeutic response to interferon beta-1a treatment in remitting-relapsing MS.
MedLine Citation:
PMID:  15351379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This pilot study was designed to determine the effects of interferon beta-1a (IFNB) therapy (Avonex) on cortically evoked motor potentials (MEPs) during resting and fatigued states in individuals with multiple sclerosis (MS). METHODS: Eight women with relapsing-remitting MS (mean age 36) and mean Expanded Disability Status Scale (EDSS) score of 3.1 were evaluated before and after 3, 6, and 12 months of IFNB therapy. At each test period, MEPs were recorded at rest and following a fatigue paradigm (3 min maximal contraction). Effects of IFNB on neurological and functional (7.7 m walk and 10 s finger tapping) status and fatigue were also examined. RESULTS: Recovery from post-exercise depression of MEP amplitudes (PED) was 41, 43, and 43.5% faster at 3, 6, and 12 months, respectively, compared to baseline (P < 0.05). Percent reduction of MEP amplitude was significantly less at 6 months (P < 0.05) The majority of subjects (5/8 at 3 months; 6/8 at 6 and 12 months) reported decreased physical fatigue. Functional improvements were observed for walk and finger tapping scores after 3 months of IFNB treatment. MEP latencies were unchanged over the course of the intervention. CONCLUSIONS: Results indicate that IFNB therapy may improve the rate of recovery from central fatigue. SIGNIFICANCE: Transcranial magnetic stimulation (TMS) may have promise as an objective physiological tool to evaluate disease activity and treatment responses in MS.
Authors:
Andrea T White; Jack H Petajan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  115     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2004-10-26     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2364-71     Citation Subset:  IM    
Affiliation:
Departments of Exercise and Sport Science and Neurology, University of Utah, 250 S. 1850 E., Rm 241, Salt Lake City, UT 84112, USA. andrea.white@health.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Disability Evaluation
Electromagnetic Fields
Electromyography
Evoked Potentials, Motor / drug effects,  physiology
Exercise / physiology
Fatigue / physiopathology
Female
Fingers / physiology
Humans
Interferon-beta / therapeutic use*
Magnetoencephalography
Motor Cortex / drug effects,  physiopathology
Multiple Sclerosis, Relapsing-Remitting / drug therapy*,  physiopathology*
Muscle Contraction / physiology
Muscle, Skeletal / physiopathology
Rest / physiology
Walking / physiology
Chemical
Reg. No./Substance:
145258-61-3/interferon beta 1a; 77238-31-4/Interferon-beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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