| Physiological insulinemia acutely modulates plasma leptin. | |
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MedLine Citation:
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PMID: 9568685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether insulin acutely regulates plasma leptin in humans is controversial. We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men (age 42+/-2 years [mean+/-SE]; BMI 29.3+/-2.0 kg/m2). Each individual underwent four 9-h euglycemic clamps (insulin at 20, 40, 80, and 400 mU x m[-2] x min[-1) and a control saline infusion. Although plasma glucose and insulin levels remained constant, leptin diminished from 9.1+/-3.0 to 5.9+/-2.1 ng/ml (P < 0.001) by the end of the control experiment. Conversely, plasma leptin showed a dosage-dependent increase during the insulin infusions that was evident within 30-60 min. The insulin-induced increase in leptin was proportionately lower in obese insulin-resistant men. Free fatty acids (FFAs) decreased during insulin and did not change during saline infusions. ED50 (the dose producing half-maximal effect) for insulin's effect on leptin and FFA was similar (138+/-36 vs. 102+/-24 pmol/l, respectively; P=0.11). To further define the role of physiological insulinemia, we compared the effect of a very low dosage insulin infusion (10 mU x m[-2] x min[-1]) with that of a control saline infusion in another group of 10 men (mean age 39+/-3 years; BMI 27.1+/-1.0 kg/m2). Plasma leptin remained stable during that insulin infusion, but fell by 37+/-2% in the control experiment. Thus physiological insulinemia can acutely regulate plasma leptin. Insulin could mediate the effect of caloric intake on leptin and could be a determinant of its plasma concentration. Inadequate insulin-induced leptin production in obese and insulin-resistant subjects may contribute to the development or worsening of obesity. |
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Authors:
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M F Saad; A Khan; A Sharma; R Michael; M G Riad-Gabriel; R Boyadjian; S D Jinagouda; G M Steil; V Kamdar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Diabetes Volume: 47 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-05-07 Completed Date: 1998-05-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 544-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Southern California Medical School, Los Angeles 90024, USA. msaad@med1.medsch.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Dose-Response Relationship, Drug Fatty Acids, Nonesterified / blood Humans Infusions, Intravenous Insulin / administration & dosage, blood*, pharmacology Insulin Resistance Leptin Male Obesity / blood Proteins / metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR-43/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Leptin; 0/Proteins; 11061-68-0/Insulin |
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