| Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. | |
| | |
MedLine Citation:
|
PMID: 20875409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rotational inertial forces are thought to be the underlying mechanism for most severe brain injuries. However, little is known about the effect of head rotation direction on injury outcomes, particularly in the pediatric population. Neonatal piglets were subjected to a single non-impact head rotation in the horizontal, coronal, or sagittal direction, and physiological and histopathological responses were observed. Sagittal rotation produced the longest duration of unconsciousness, highest incidence of apnea, and largest intracranial pressure increase, while coronal rotation produced little change, and horizontal rotation produced intermediate and variable derangements. Significant cerebral blood flow reductions were observed following sagittal but not coronal or horizontal injury compared to sham. Subarachnoid hemorrhage, ischemia, and brainstem pathology were observed in the sagittal and horizontal groups but not in a single coronal animal. Significant axonal injury occurred following both horizontal and sagittal rotations. For both groups, the distribution of injury was greater in the frontal and parietotemporal lobes than in the occipital lobes, frequently occurred in the absence of ischemia, and did not correlate with regional cerebral blood flow reductions. We postulate that these direction-dependent differences in injury outcomes are due to differences in tissue mechanical loading produced during head rotation. |
| | |
Authors:
|
Stephanie A Eucker; Colin Smith; Jill Ralston; Stuart H Friess; Susan S Margulies |
Related Documents
:
|
2218079 - Experimental analysis of gastric mucosal blood flow after transient forebrain ischemia. 11313789 - Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabb... 12538999 - Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cari... 14732349 - A noninvasive murine model of hind limb ischemia-reperfusion injury. 2160209 - The role of leukocyte depletion by in vivo use of leukocyte filter in lung preservation... 1992239 - Studies of controlled reperfusion after ischemia. xix. reperfusate composition: benefit... 16888079 - Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: ii. an effic... 20595819 - Application of ultrasound dilution technology for cardiac output measurement: cerebral ... 11133269 - Alzheimer's disease: a review concerning immune response and microischemia. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-25 |
Journal Detail:
|
Title: Experimental neurology Volume: 227 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-10 Completed Date: 2011-02-04 Revised Date: 2012-01-04 |
Medline Journal Info:
|
Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 79-88 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Animals, Newborn Brain / pathology Cerebrovascular Circulation / physiology* Diffuse Axonal Injury / etiology Disease Models, Animal Head Injuries, Closed / pathology*, physiopathology Head Movements / physiology* Hypoxia-Ischemia, Brain / etiology, pathology Motion* Rotation / adverse effects* Severity of Illness Index Subarachnoid Hemorrhage / etiology, veterinary Swine |
| Grant Support | |
ID/Acronym/Agency:
|
R01 NS039679-07/NS/NINDS NIH HHS; R01 NS039679-08/NS/NINDS NIH HHS; R01 NS039679-09/NS/NINDS NIH HHS; R01 NS039679-10/NS/NINDS NIH HHS; R01 NS39679/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Membrane-associated signaling in human B-lymphoma lines.
Next Document: A colorimetric method for the evaluation of anti-giardial drugs in vitro.