Document Detail


Physiological evidence for ipsilateral inhibition in the lateral superior olive: synaptic responses in mouse brain slice.
MedLine Citation:
PMID:  8157506     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of ipsilateral inhibition in the lateral superior olive (LSO) was examined in a brain slice preparation of the mouse superior olivary complex. A 400 microns brain slice was taken in the frontal plane and maintained in a warm, oxygenated saline solution. Intracellular recordings were made from the LSO with micropipettes filled with 4 M potassium acetate. Synaptic responses were elicited by electrical stimulation of the trapezoid body in different slices at various locations between the cochlear nucleus and the ipsilateral superior olivary complex (SOC). The results show that ipsilateral stimulation can evoke inhibitory as well as excitatory postsynaptic potentials. The ipsilateral IPSPs have short latencies and are elicited by stimulation of the trapezoid body at any point along its course between cochlear nucleus and LSO. Short-latency IPSPs can also be produced by direct stimulation of the ventral cochlear nucleus itself. Ipsilateral IPSPs are blocked by low concentrations of the glycine antagonist, strychnine. In addition, bath application of sodium pentobarbital in one case eliminated ipsilateral IPSPs without eliminating EPSPs. The results suggest that there is a rapidly conducting, glycinergic pathway from cochlear nucleus through the trapezoid body to the LSO on the same side of the brain. This pathway is probably served by either a direct projection from the ventral cochlear nucleus to the LSO or an indirect one from cochlear nucleus to LSO through the lateral nucleus of the trapezoid body (LNTB).
Authors:
S H Wu; J B Kelly
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  73     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Affiliation:
Department of Psychology, Carleton University, Ottawa, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials
Animals
Cochlear Nucleus / physiology*
Electric Stimulation
Mice
Mice, Inbred C57BL
Neural Inhibition*
Olivary Nucleus / physiology*
Pons / physiology*
Strychnine / pharmacology
Synaptic Transmission* / drug effects
Chemical
Reg. No./Substance:
57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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