Document Detail

Physiological evaluation of the provisional side-branch intervention strategy for bifurcation lesions using fractional flow reserve.
MedLine Citation:
PMID:  18308689     Owner:  NLM     Status:  MEDLINE    
AIMS: This study was performed to evaluate the functional outcomes of fractional flow reserve (FFR)-guided jailed side-branch (SB) intervention strategy. METHODS AND RESULTS: One hundred and ten patients treated by provisional strategy were consecutively enrolled and SB FFR was measured in 91 patients. SB intervention was allowed when FFR was <0.75. FFR measurement was repeated after SB intervention and at 6-month follow-up angiography. In 26 of 28 SB lesions with FFR <0.75, balloon angioplasty (SB balloon/artery ratio = 0.84 +/- 0.14) was performed and FFR >or=0.75 was achieved in 92% of the lesions although the mean residual stenosis was 69 +/- 10%. During follow-up, there were no changes in SB FFR in lesions with (0.86 +/- 0.05 to 0.84 +/- 0.01, P = 0.4) and without SB angioplasty (0.87 +/- 0.06 to 0.89 +/- 0.07, P = 0.1). Functional restenosis (FFR <0.75) rate was only 8% (5/65). When clinical outcomes of these patients were compared with 110 patients with similar bifurcation lesions treated without FFR-guidance, there was no difference in 9-month cardiac event rates (4.6 vs. 3.7%, P = 0.7) between the two groups. CONCLUSION: In conclusion, FFR-guided SB intervention strategy resulted in good functional outcomes.
Bon-Kwon Koo; Kyung-Woo Park; Hyun-Jae Kang; Young-Seok Cho; Woo-Young Chung; Tae-Jin Youn; In-Ho Chae; Dong-Ju Choi; Seung-Jae Tahk; Byung-Hee Oh; Young-Bae Park; Hyo-Soo Kim
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-28
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  726-32     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Yongon-dong 28, Jongno-gu, Seoul 110-744, Republic of Korea.
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MeSH Terms
Balloon Dilatation
Coronary Stenosis / drug therapy,  physiopathology*
Death, Sudden, Cardiac / etiology
Drug-Eluting Stents
Follow-Up Studies
Fractional Flow Reserve, Myocardial / physiology*
Middle Aged
Myocardial Infarction / etiology
Myocardial Revascularization / statistics & numerical data
Treatment Outcome
Comment In:
Eur Heart J. 2008 Mar;29(6):704-6   [PMID:  18343799 ]

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