Document Detail

Physiological effects of intermittent hypoxia.
MedLine Citation:
PMID:  11256564     Owner:  NLM     Status:  MEDLINE    
Intermittent hypoxia (IH), or periodic exposure to hypoxia interrupted by return to normoxia or less hypoxic conditions, occurs in many circumstances. In high altitude mountaineering, IH is used to optimize acclimatization although laboratory studies have not generally revealed physiologically significant benefits. IH enhances athletic performance at sea level if blood oxygen capacity increases and the usual level of training is not decreased significantly. IH for high altitude workers who commute from low altitude homes is of considerable practical interest and the ideal commuting schedule for physical and mental performance is being studied. The effect of oxygen enrichment at altitude (i.e., intermittent normoxia on a background of chronic hypoxia) on human performance is under study also. Physiological mechanisms of IH, and specifically the differences between effects of IH and acute or chronic continuous hypoxia remains to be determined. Biomedical researchers are defining the molecular and cellular mechanisms for effects of hypoxia on the body in health and disease. A comparative approach may provide additional insight about the biological significance of these effects.
F L Powell; N Garcia
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  1     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2000  
Date Detail:
Created Date:  2001-03-20     Completed Date:  2001-04-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-36     Citation Subset:  IM; S    
Department of Medicine, University of California San Diego, La Jolla, USA.
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MeSH Terms
Acclimatization / physiology*
Altitude Sickness / blood,  physiopathology*,  prevention & control*
Anoxia / blood,  physiopathology*,  prevention & control*
Exercise Therapy / methods
Oxygen Inhalation Therapy
Physical Education and Training / methods
Polycythemia / etiology
Sleep Apnea Syndromes / blood,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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