Document Detail

Physiological effects of acute passive exposure to cigarette smoke.
MedLine Citation:
PMID:  686848     Owner:  NLM     Status:  MEDLINE    
Effects of passive inhalation of cigarette smoke at levels typically encountered in public buildings have been investigated. Twenty normal male and female nonsmokers (18 to 30 years) were each exposed for two hours on alternate days (in random order) to either room air or room air plus machine-produced cigarette smoke. Exposures were conducted in an unventilated chamber (14.6 m3). Subdivisions of lung volume, maximum expiratory flow-volume curves, single-breath nitrogen washout curves, blood carboxyhemoglobin levels, and heart rates were obtained before, during, and after exposure. A submaximal bicycle ergometer test and a symptom questionnaire were also administered after exposure. Statistical analysis revealed several significant differences between test and control days; the magnitude of the changes was small and of questionable biological significance, however, particularly when account was taken of the number of statistical comparisons made. Despite the relatively small physiological changes, subjective complaints were common-cough, and eye irritation, for example. It is concluded that in normal subjects the magnitude of physiological responses to acute exposures is minimal; thus arguments concerning effects rest on symptomatology and such other factors as the unknown risks of chronic exposure.
P E Pimm; R J Shephard; F Silverman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of environmental health     Volume:  33     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1978 Jul-Aug
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  201-13     Citation Subset:  AIM; IM    
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MeSH Terms
Air Pollutants
Carbon Monoxide
Carboxyhemoglobin / blood
Environmental Exposure
Heart Rate
Lung Volume Measurements
Physical Exertion
Plants, Toxic*
Pulmonary Ventilation
Reg. No./Substance:
0/Air Pollutants; 0/Smoke; 630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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