| Physiological distribution of digoxin in human heart. | |
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MedLine Citation:
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PMID: 4280329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumably reflecting binding to a possible receptor site, is uniform. When the histological abnormality is focal then digoxin distribution is uniform.These results suggest that in the presence of myocardial ischaemia plasma digoxin concentrations may not reflect total myocardial levels accurately. |
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Authors:
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D J Coltart; H G Güllner; M Billingham; R H Goldman; E B Stinson; S M Kalman; D C Harrison |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British medical journal Volume: 4 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1974 Dec |
Date Detail:
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Created Date: 1975-04-14 Completed Date: 1975-04-14 Revised Date: 2010-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 733-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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analysis Adult Blood Urea Nitrogen / analysis Cardiomyopathy, Hypertrophic / drug therapy, pathology Coronary Disease / drug therapy, pathology Digoxin / analysis*, therapeutic use Female Heart Atria / analysis Heart Transplantation Heart Ventricles / analysis Humans Magnesium / analysis Male Microsomes / analysis Middle Aged Myocardium / analysis*, pathology Potassium / analysis Radioimmunoassay Sodium / analysis Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.6.1.-/Adenosine Triphosphatases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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