|Physiological distribution of digoxin in human heart.|
|PMID: 4280329 Owner: NLM Status: MEDLINE|
|Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumably reflecting binding to a possible receptor site, is uniform. When the histological abnormality is focal then digoxin distribution is uniform.These results suggest that in the presence of myocardial ischaemia plasma digoxin concentrations may not reflect total myocardial levels accurately.|
|D J Coltart; H G Güllner; M Billingham; R H Goldman; E B Stinson; S M Kalman; D C Harrison|
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|Type: Journal Article|
|Title: British medical journal Volume: 4 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1974 Dec|
|Created Date: 1975-04-14 Completed Date: 1975-04-14 Revised Date: 2010-10-26|
Medline Journal Info:
|Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND|
|Languages: eng Pagination: 733-6 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Blood Urea Nitrogen / analysis
Cardiomyopathy, Hypertrophic / drug therapy, pathology
Coronary Disease / drug therapy, pathology
Digoxin / analysis*, therapeutic use
Heart Atria / analysis
Heart Ventricles / analysis
Magnesium / analysis
Microsomes / analysis
Myocardium / analysis*, pathology
Potassium / analysis
Sodium / analysis
|20830-75-5/Digoxin; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.6.1.-/Adenosine Triphosphatases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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