Document Detail

Physiological distribution of digoxin in human heart.
MedLine Citation:
PMID:  4280329     Owner:  NLM     Status:  MEDLINE    
Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumably reflecting binding to a possible receptor site, is uniform. When the histological abnormality is focal then digoxin distribution is uniform.These results suggest that in the presence of myocardial ischaemia plasma digoxin concentrations may not reflect total myocardial levels accurately.
D J Coltart; H G Güllner; M Billingham; R H Goldman; E B Stinson; S M Kalman; D C Harrison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  4     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1974 Dec 
Date Detail:
Created Date:  1975-04-14     Completed Date:  1975-04-14     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  733-6     Citation Subset:  AIM; IM    
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MeSH Terms
Adenosine Triphosphatases / analysis
Blood Urea Nitrogen / analysis
Cardiomyopathy, Hypertrophic / drug therapy,  pathology
Coronary Disease / drug therapy,  pathology
Digoxin / analysis*,  therapeutic use
Heart Atria / analysis
Heart Transplantation
Heart Ventricles / analysis
Magnesium / analysis
Microsomes / analysis
Middle Aged
Myocardium / analysis*,  pathology
Potassium / analysis
Sodium / analysis
Transplantation, Homologous
Reg. No./Substance:
20830-75-5/Digoxin; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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