| Physiological correlates of attenuated salt appetite in Fischer 344 rats. | |
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MedLine Citation:
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PMID: 8140178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary NaCl deprivation stimulates a robust salt appetite in Wistar rats but has little influence on this behavior in rats of the Fischer 344 (F344) strain. To examine physiological substrates of attenuated salt appetite in F344 rats, several pertinent measures of renal function and fluid homeostasis were made in Wistar and F344 rats eating normal and NaCl-deplete diets. Physiological adjustments to NaCl deprivation were similar between the two strains; however, F344 rats showed smaller increases in plasma renin activity (PRA) than their Wistar counterparts. In addition, F344s decreased urinary sodium excretion more rapidly than Wistar rats in response to deprivation. The present studies also revealed several strain differences in baseline fluid and electrolyte regulation. Relative to the Wistar strain, F344 rats were characterized by high baseline PRA, increased arginine vasopressin (AVP) excretion, decreased urine volume, and diminished thirst. We propose that AVP and oxytocin activation may reduce salt preference and suppress the development of salt appetite in F344 rats. |
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Authors:
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M Muntzel; B Lacour; B Pouzet; G Geelen; T Drüeke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 55 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-04-25 Completed Date: 1994-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 77-82 Citation Subset: IM |
Affiliation:
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INSERM Unité 90, Department of Nephrology, Hôpital Necker, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite / physiology* Diet, Sodium-Restricted Kidney Function Tests Male Natriuresis / physiology Rats Rats, Inbred F344 Rats, Wistar Renal Circulation / physiology Renin-Angiotensin System / physiology Sodium, Dietary / administration & dosage* Species Specificity Water-Electrolyte Balance / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Sodium, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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