Document Detail


Physiological control of germline development.
MedLine Citation:
PMID:  22872476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intersection between developmental programs and environmental conditions that alter physiology is a growing area of research interest. The C. elegans germ line is emerging as a particularly sensitive and powerful model for these studies. The germ line is subject to environmentally regulated diapause points that allow worms to withstand harsh conditions both prior to and after reproduction commences. It also responds to more subtle changes in physiological conditions. Recent studies demonstrate that different aspects of germ line development are sensitive to environmental and physiological changes and that conserved signaling pathways such as the AMPK, Insulin/IGF, TGFβ, and TOR-S6K, and nuclear hormone receptor pathways mediate this sensitivity. Some of these pathways genetically interact with but appear distinct from previously characterized mechanisms of germline cell fate control such as Notch signaling. Here, we review several aspects of hermaphrodite germline development in the context of "feasting," "food-limited," and "fasting" conditions. We also consider connections between lifespan, metabolism and the germ line, and we comment on special considerations for examining germline development under altered environmental and physiological conditions. Finally, we summarize the major outstanding questions in the field.
Authors:
E Jane Albert Hubbard; Dorota Z Korta; Diana Dalfó
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  757     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-08     Completed Date:  2012-11-29     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / cytology*,  growth & development,  metabolism*
Caenorhabditis elegans Proteins / metabolism*
Cell Physiological Phenomena*
Germ Cells / cytology*
Grant Support
ID/Acronym/Agency:
F30 DK089697/DK/NIDDK NIH HHS; F30DK089697/DK/NIDDK NIH HHS; R01 GM061706/GM/NIGMS NIH HHS; R01GM061706/GM/NIGMS NIH HHS; R03 HD066005/HD/NICHD NIH HHS; R03HD066005/HD/NICHD NIH HHS; T32 GM007308/GM/NIGMS NIH HHS; T32GM07308/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins
Comments/Corrections

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