| Physiological control of germline development. | |
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MedLine Citation:
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PMID: 22872476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intersection between developmental programs and environmental conditions that alter physiology is a growing area of research interest. The C. elegans germ line is emerging as a particularly sensitive and powerful model for these studies. The germ line is subject to environmentally regulated diapause points that allow worms to withstand harsh conditions both prior to and after reproduction commences. It also responds to more subtle changes in physiological conditions. Recent studies demonstrate that different aspects of germ line development are sensitive to environmental and physiological changes and that conserved signaling pathways such as the AMPK, Insulin/IGF, TGFβ, and TOR-S6K, and nuclear hormone receptor pathways mediate this sensitivity. Some of these pathways genetically interact with but appear distinct from previously characterized mechanisms of germline cell fate control such as Notch signaling. Here, we review several aspects of hermaphrodite germline development in the context of "feasting," "food-limited," and "fasting" conditions. We also consider connections between lifespan, metabolism and the germ line, and we comment on special considerations for examining germline development under altered environmental and physiological conditions. Finally, we summarize the major outstanding questions in the field. |
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Authors:
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E Jane Albert Hubbard; Dorota Z Korta; Diana Dalfó |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 757 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-08-08 Completed Date: 2012-11-29 Revised Date: 2013-04-24 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 101-31 Citation Subset: IM |
Affiliation:
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Department of Pathology, New York University School of Medicine, New York, NY 10016, USA. jane.hubbard@med.nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / cytology*, growth & development, metabolism* Caenorhabditis elegans Proteins / metabolism* Cell Physiological Phenomena* Germ Cells / cytology* |
| Grant Support | |
ID/Acronym/Agency:
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F30DK089697/DK/NIDDK NIH HHS; R01 GM061706/GM/NIGMS NIH HHS; R01GM061706/GM/NIGMS NIH HHS; R03 HD066005/HD/NICHD NIH HHS; R03HD066005/HD/NICHD NIH HHS; T32GM07308/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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